Greater Sweat Reduction for Aluminum Chloride Hexahydrate

Twenty percent aluminum chloride hexahydrate more effective than 1 percent aluminum acetate

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TUESDAY, Dec. 15, 2015 (HealthDay News) -- Twenty percent aluminum chloride hexahydrate reduces axillary sweating more effectively than 1 percent aluminum acetate, according to a study published in the December issue of the Journal of Cosmetic Dermatology.

Jillian H. Swary, M.D., from the Feinberg School of Medicine at Northwestern University in Chicago, and colleagues compared the efficacy of two aluminum salt solutions for reduction of induced sweating. Nineteen subjects were exposed to a standardized heat challenge for three hours. Axillae were treated with topical agent A (20 percent aluminum chloride hexahydrate) on one side and topical agent B (1 percent aluminum acetate) on the contralateral side. Sweating was induced during three 30-minute heat intervals: with no study agents, with both study agents (one on each side), and after the agents were washed off.

The researchers observed significantly greater reduction in axillary sweating with topical agent A versus topical agent B (P = 0.0002).

"In a sweating simulation, 20 percent aluminum chloride hexahydrate quantitatively and objectively appeared to reduce sweat more effectively than 1 percent aluminum acetate," the authors write.

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