Here are what the editors at HealthDay consider to be the most important developments in Dermatology for July 2011. This roundup includes the latest research news from journal articles, as well as the FDA approvals and regulatory changes that are the most likely to affect clinical practice.
Testosterone Ranges Set Up for Premenopausal Women
FRIDAY, July 29 (HealthDay News) -- Using validated immunoassays, reference ranges for free, total, and bioavailable testosterone and sex hormone-binding globulin (SHBG) have been established using the fifth and 95th percentiles in premenopausal women with normal menstrual cycles, according to a study published online July 19 in The Journal of Sexual Medicine.
Somatic Mosaicism in AKT1 Causes Proteus Syndrome
WEDNESDAY, July 27 (HealthDay News) -- A somatic activating mutation in the oncogene AKT1 has been found to cause Proteus syndrome, a condition characterized by the overgrowth of skin, connective tissue, brain, and other tissues, according to a study published online July 27 in the New England Journal of Medicine.
PTEN Downregulation Impairs UVB-Induced DNA Damage Repair
WEDNESDAY, July 27 (HealthDay News) -- Downregulation of the tumor suppressor PTEN suppresses xeroderma pigmentosum C (XPC)-dependent genomic nucleotide excision repair (GG-NER), according to an experimental study published online July 19 in Cancer Research.
Skin Self-Exam Increases Transiently With DVD Use
FRIDAY, July 22 (HealthDay News) -- Targeted interventions increase the proportion of men 50 years and older conducting skin self-examination (SSE), but additional DVD or video-based intervention shows no benefit over written material at 13 months, according to a study published in the July issue of the Archives of Dermatology.
Physician Screening Increases Melanoma Detection Rate
FRIDAY, July 22 (HealthDay News) -- Physician-based screening is associated with higher melanoma detection and detection of thinner melanomas, according to a study published online July 18 in the Archives of Dermatology.
Greater Sun Safety Linked to Acculturation in Latinos
THURSDAY, July 21 (HealthDay News) -- Use of sunscreen, shade, and sun-protective clothing when outdoors on warm, sunny days is associated with acculturation among Latinos in the United States, while perceived health status, educational level, and contact with social networks regarding health matters mediate a positive association between acculturation and sunscreen use, according to a study published in the July issue of the Archives of Dermatology.
Quinacrine + Hydroxychloroquine Effective in Cutaneous Lupus
THURSDAY, July 21 (HealthDay News) -- Patients with cutaneous lupus erythematosus (CLE) who fail to respond to hydroxychloroquine alone may respond to the addition of quinacrine, but may also benefit from continuation of hydroxychloroquine monotherapy despite initial lack of response, according to a study published online July 18 in the Archives of Dermatology.
Distinct T Cells Tied to Psoriasis, Atopic Eczema Pathogenesis
THURSDAY, July 21 (HealthDay News) -- Distinct antigen-specific T-cell responses may play a role in the pathogenesis of psoriasis and atopic eczema, according to a study published in the July 21 issue of the New England Journal of Medicine.
BetaPV Infection Tied to SCC in Transplant Recipients
MONDAY, July 18 (HealthDay News) -- There is a significant association between betapapillomavirus (betaPV) infection and squamous cell carcinoma (SCC) in patients who receive organ transplants, according to a study published in the July issue of the American Journal of Transplantation.
Child Immune Response Tied to Mothers' Cytokine Production
FRIDAY, July 15 (HealthDay News) -- Maternal inflammatory cytokines in pregnancy are associated with the corresponding cytokine levels in children at age 1 year, but children's atopic dermatitis is only associated with maternal atopic dermatitis, according to a study published in the August issue of Allergy.
Associations Found Between Contact Allergy and Cancer
WEDNESDAY, July 13 (HealthDay News) -- An inverse association has been found between contact allergy and non-melanoma skin and breast cancer, and a positive association between contact allergy and bladder cancer, according to a study published online July 11 in BMJ Open.
Vitamin D Insufficiency Prevalent in Psoriatic Arthritis
MONDAY, July 11 (HealthDay News) -- Patients with psoriatic arthritis (PsA) have a high prevalence of vitamin D insufficiency, with no evidence of seasonal or geographic variation or association between vitamin D levels and disease activity, according to a study published online July 11 in Arthritis Care & Research.
Cardiac Transplants Tied to Increased Risk of Skin Cancer
MONDAY, July 11 (HealthDay News) -- Patients who have undergone cardiac transplants have an increased risk of developing skin cancer, in particular cutaneous squamous cell carcinoma (SCC), compared to the general population, according to a study published in the July issue of the American Journal of Transplantation.
Transcutaneous Ultrasound Appears Safe for Asian Skin
FRIDAY, July 1 (HealthDay News) -- Transcutaneous focused ultrasound may be a safe non-invasive skin-tightening procedure for Asians, according to a study published in the July issue of Lasers in Surgery and Medicine.