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Treatment Encouraged for Venous Leg Ulcer Patients

Less than 40 percent fully comply with compression therapy

WEDNESDAY, Oct. 17 (HealthDay News) -- Patients with venous leg ulcers are typically not as physically active as they should be, and need encouragement and education to fully comply with treatment, according to study findings published in the October issue of the Archives of Dermatology. In another study, β-adrenergic receptor agonists show promise as a possible treatment for venous leg ulcers.

Maud M. Heinen, Ph.D., of Radboud University Nijmegen Medical Centre in Nijmegen, the Netherlands, and colleagues report that of the 150 patients with leg ulcers that they studied, only 39 percent fully complied with compression therapy and 35 percent of patients did not even have a 10-minute once-weekly walk.

David J. Margolis, M.D., Ph.D., of the University of Pennsylvania School of Medicine in Philadelphia, and colleagues conducted a study of 62,886 patients who were exposed to a β-adrenergic receptor agonist and 54,861 who were exposed to a β-adrenergic receptor antagonist. There were 6,620 subjects exposed to both.

"A protective association between β-adrenergic receptor agonists and perhaps β-adrenergic receptor antagonists and venous leg ulcers exists," Margolis and colleagues write. "The evidence in this study should not be used as a rationale for treatment of venous leg ulcers with β-adrenergic receptor agents but should be compelling for the consideration of a randomized, controlled trial."

Abstract - Heinen
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Abstract - Margolis
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