Wells Syndrome Is Skin Condition Only

Eosinophilic disease has seven variants, but no systemic involvement

TUESDAY, Sept. 26 (HealthDay News) -- The Wells syndrome is a distinct diagnosis based on clinicopatholologic characteristics and includes only the skin, with no systemic involvement, according to a paper in the September issue of the Archives of Dermatology.

Ruggero Caputo, M.D., of the University of Milan in Italy, and colleagues reviewed records of 19 patients with Wells syndrome. Type and prevalence of the skin lesions, treatment response and potentially linked systemic symptoms were analyzed. Histologic and laboratory findings were also evaluated.

The investigators noted seven variants of the disease, with the plaque type most common in children, who also had more unilesional forms. In adults, the disease most often presented as the annular granuloma variant. Both adults and children had recurrent, slowly progressive disease courses with a mean duration of five years and three years, respectively.

"Although it should be classified within a spectrum that includes multi-system eosinophilic disorders, such as Churg-Strauss and hypereosinophilic syndromes, Wells syndrome, which has seven variants, is a distinct cutaneous disease lacking systemic involvement," the authors conclude.

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