In Androgenetic Alopecia, Early Cardiac Screening Important

CV risk factors more prevalent among early-onset androgenetic alopecia patients than controls

FRIDAY, Aug. 20 (HealthDay News) -- Patients with early-onset androgenetic alopecia (AGA) have higher risk for cardiovascular disease and should be screened early to determine the need for preventive treatment, according to a study in the September issue of the Journal of the American Academy of Dermatology.

Salvador Arias-Santiago, M.D., of the San Cecilio University Hospital in Granada, Spain, and colleagues compared 40 male and 37 female subjects with AGA to a healthy control group of 40 males and 37 females. The groups were analyzed for cardiovascular risk factors, including metabolic syndrome, carotid atheromatosis, hormonal factors, and acute phase reactant variables.

The researchers found metabolic syndrome present in 60 percent of male and 48.6 percent of female AGA patients, compared to 12.5 percent of male and 8.1 percent of female controls. Atheromatous plaques were found in 32.5 percent of male and 27 percent of female AGA patients compared to 7.5 percent of male and 8.1 percent of female control subjects. Aldosterone and insulin levels were significantly higher in the male and female AGA patients than the controls. Compared to controls, fibrinogen values were higher in male AGA patients, while fibrogen, C-reactive protein, and D-dimers were higher in female AGA patients. The authors concluded that determination of metabolic syndrome along with ultrasound study of carotid arteries may be useful for detecting cardiovascular disease risk in early-onset AGA patients and signal a possible opportunity for early prevention.

"More studies with larger numbers of patients are required to confirm these findings and to analyze the pathogenic mechanisms underlying the increase in cardiovascular risk in patients with AGA," the authors write.

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