FRIDAY, Oct. 23 (HealthDay News) -- Using a coarse-grit hand piece to conduct microdermabrasion prompts sun-damaged skin to remodel itself in a process similar to wound healing, and may be more effective in dermal remodeling than medium-grit use, according to a study in the October issue of the Archives of Dermatology.
Darius J. Karimipour, M.D., of the University of Michigan in Ann Arbor, and colleagues conducted a study of 40 adults aged 50 to 83 years who had clinically photodamaged forearms and who underwent focal microdermabrasion and provided skin biopsies after treatment with hand pieces of varied abrasiveness.
When the subjects underwent coarse-grain microdermabrasion, the skin responded by producing a wound-healing response of rapidly increased cytokeratin 16 production, and activation of the AP-1 transcription factor in the epidermis, the researchers discovered. Dermal remodeling also occurred with induction of types I and III procollagen and collagen production enhancers, the investigators report, while a medium-grit hand piece did not generate the same dermal remodeling results.
"Optimization of these molecular effects is likely the result of more aggressive treatment with a more abrasive hand piece," the authors write. "To the extent that molecular changes can predict clinical outcome, aggressive coarse-grit microdermabrasion should elicit significant skin rejuvenation. Further studies will determine whether microdermabrasion, if performed aggressively, has the capacity to become a worthwhile resurfacing procedure that results in noticeable cosmetic improvement while minimizing patient morbidity and downtime."
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