Grape Seed Extract Lowers Squamous Cell Carcinoma Risk

Use of multivitamins is linked to borderline significant reduction in the risk of SCC

MONDAY, Nov. 21 (HealthDay News) -- Use of grape seed extract is associated with a reduced risk of cutaneous squamous cell carcinoma (SCC), according to a study published in the December issue of the Journal of the American Academy of Dermatology.

Maryam M. Asgari, M.D., M.P.H., from Kaiser Permanente Northern California in Oakland, and colleagues assessed the correlation between dietary supplements and SCC risk in 415 patients with a pathology-verified SCC in 2004 and 415 age-, gender-, and race- matched control subjects with no history of skin cancer. Questionnaires were used to ascertain supplement use and SCC risk factors. The correlations between SCC and use of multivitamins; vitamins A, C, D, and E; and grape seed extract were evaluated, after adjusting for SCC risk factors and other supplement use.

The investigators found a significantly reduced risk of cutaneous SCC in grape seed extract users (adjusted odds ratio [aOR], 0.26; P = .031). A borderline significant reduction in SCC risk was found with the use of multivitamins (aOR, 0.7; P = .049). There was no association between use of vitamins A, C, D, and E and SCC risk

"Use of grape seed extract may be associated with a decreased risk of cutaneous SCC. The other supplements included in our study did not reveal clear associations with SCC risk," the authors write.

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