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Epidermal Nevi, Urothelial Carcinomas Share Mutation

FGFR3 mutations found in seborrheic keratosis and urothelial carcinoma can occur in epidermal nevi

THURSDAY, July 26 (HealthDay News) -- Mutations in fibroblast growth factor receptor 3 (FGFR3), which are found in seborrheic keratosis and urothelial carcinomas, are also found in some epidermal nevi, according to a study in the July issue of the Journal of Investigative Dermatology.

Silvia Hernandez of the Universitat Pompeu Fabra in Barcelona, Spain, and colleagues reviewed the epidermal nevi of 23 patients and the nevi and urothelial carcinoma tissues of two patients with both conditions. Microdissection, DNA extraction and PCR amplification of FGFR3 were performed.

The R248C FGFR3 mutation was found in 26 percent of the epidermal nevi tissues tested, but was absent from unaffected skin. In the two patients with epidermal nevi and urothelial carcinoma, both lesions contained wildtype FGFR3, rather than mutations.

"Evidence is growing that these mutations are also involved in the pathogenesis of benign acanthotic skin tumors such as epidermal nevi and seborrheic keratoses," according to an accompanying commentary. "The report by Hernandez et al. strongly supports this concept. However, further studies are required for a better pathogenetic understanding of FGFR3-related tumors in urothelium and skin."

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