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Overall Survival Worse With Multiple Primary Melanomas

Median Breslow thickness decreased from 0.90 mm for first melanoma to 0.65 mm for second melanoma

skin cancer

FRIDAY, June 28, 2019 (HealthDay News) -- Patients with multiple primary melanomas have worse overall survival than those with a single primary melanoma, according to a study published online June 26 in JAMA Dermatology.

Mary-Ann El Sharouni, M.D., from the University Medical Center Utrecht in the Netherlands, and colleagues described the epidemiologic features of multiple primary melanoma in a retrospective population-based cohort study. Adults with histologically proven, primary, invasive cutaneous melanoma during Jan. 1, 2000, through Dec. 31, 2014, were followed for a median of 75.1 months. Data were included for 56,929 patients total (54,645 single primary melanomas and 4,967 multiple primary melanomas in 2,284 patients).

The researchers found a decrease in the median Breslow thickness from 0.90 mm for the first melanoma to 0.65 mm for the second melanoma. For the second melanoma, 16.2 percent of patients had a higher T stage, 48.7 percent had the same T stage, and 35.1 percent had a lower T stage. In patients with multiple primary melanomas, 36.8 and 27.3 percent were found during the first year of follow-up and after five years of follow-up, respectively. Patients with multiple primary melanomas had worse overall survival than those with a single primary melanoma (hazard ratio, 1.31).

"The findings suggest that current melanoma follow-up strategies need to be reconsidered for patients with multiple primary melanomas and guidelines should comment on this," the authors write.

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