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Botox Before Chemabrasion Reduces Wrinkle Severity

Results seen in upper lip region at 90 days

FRIDAY, Sept. 28 (HealthDay News) -- Injections of botulinum toxin type A before chemabrasion reduces the severity of vertical wrinkles in the upper lip region after as little as 90 days, researchers report in the September issue of Dermatologic Surgery.

Bogdana V. Kadunc, Ph.D., and colleagues from Hospital do Servidor Publico Municipal in Sao Paulo, Brazil, pretreated the orbicularis oris muscle of 12 women (aged 47 to 69 years old) who had moderate to severe upper lip vertical rhytides, with botulinum toxin type A one week before manual chemabrasion. Patients received two unilateral botulinum toxin injections at the vermilion border while the other side was injected similarly with saline.

The researchers found that starting at 90 days and up to three years, there was a significant improvement in wrinkle severity on the toxin-treated side, as assessed by the four-point Facial Wrinkle Severity Scale.

"Previous injections of botulinum toxin type A improve short- and long-term results of chemabrasion in the upper lip region," Kadunc and colleagues conclude.

One of the study authors is a consultant for Allergan, maker of Botox.

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