Lasers Promote Collagen Synthesis in Skin of Mice

Findings could have implications for treatment of scars and other skin lesions in humans

THURSDAY, Jan. 31 (HealthDay News) -- Laser irradiation of the skin promotes collagen synthesis and remodeling in a mouse model, according to an article published online Jan. 25 in Lasers in Surgery and Medicine.

Huaxu Liu, M.D., Ph.D., of Shanghai Jiao Tong University in Shanghai, China, and colleagues studied the mechanics of laser-induced collagen remodeling in a mouse model by depilating and irradiating the skin of mice with different laser treatment parameters, including the 595-nm wavelength pulsed dye laser, 1,320-nm Nd:YAG laser and 1,064-nm long-pulsed and Q-switched Nd:YAG lasers. Histologic changes, fibroblast number and production of collagen in irradiated sites was compared to that of control sites at one hour, one day and one, three, four and eight weeks post-treatment.

All of the laser treatments were effective in improving dermal layer thickness, collagen fiber density, fibroblast number and hydroxyproline content compared to controls. Of the four laser treatments, the Q-switched 1,064-nm laser was most effective in improving collagen synthesis and remodeling at four weeks.

"Our results demonstrated a high correlation between collagen remodeling and laser-tissue effects. We observed that all the four laser irradiation modalities could promote collagen synthesis and remodeling of…mice skin, and that fibroblast proliferation correlated with collagen synthesis," write the authors. "Similar comparative studies in human clinical settings are needed to confirm the results achieved in our in vivo experiments."

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