Photosensitizer, Pulsed-Light Therapy Removes Wrinkles

Combination works better than intense pulsed light alone

THURSDAY, Oct. 20 (HealthDay News) -- The combination of intense pulsed light (IPL) with 5-aminolevulinic acid (5-ALA) works better than IPL alone to treat facial photoaging, according to a study in the October issue of the Archives of Dermatology.

Jeffrey S. Dover, M.D., of Yale University School of Medicine, and colleagues conducted the split-face study of 20 patients. In three split-face treatments done three weeks apart, half the faces were treated with 5-ALA followed by IPL and half with IPL only. The patients then received two more full-face IPL treatments three weeks apart. A blinded investigator assessed global photodamage, fine lines, mottled pigmentation, tactile roughness and sallowness. Patients also assessed their own progress by comparing their results with pretreatment photographs.

The researchers found that pretreatment with 5-ALA resulted in more improvement in photoaging and mottled pigmentation than IPL alone.

"The adjunctive use of 5-ALA in the treatment of facial photoaging with IPL provides significantly greater improvement in global photodamage, mottled pigmentation and fine lines than treatment with IPL alone," the authors write. The study was funded by Dusa Pharmaceuticals.

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