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FDA Warns of Joint Pain Tied to DPP-4 Inhibitors

Agency advises users with such symptoms to contact their doctor

MONDAY, Aug. 31, 2015 (HealthDay News) -- Use of dipeptidyl peptidase-4 (DPP-4) inhibitors in type 2 diabetes is tied to severe joint pain in some patients, the U.S. Food and Drug Administration warned on Friday.

In a safety announcement, the FDA said the medications "may cause joint pain that can be severe and disabling," and the agency "has added a new Warning and Precaution about this risk to the labels of all medicines in this drug class."

The FDA stressed that patients who take a DPP-4 inhibitor should not stop using the drug, "but should contact their health care professional right away if they experience severe and persistent joint pain."

Physicians and other health care workers should "consider DPP-4 inhibitors as a possible cause of severe joint pain and discontinue the drug if appropriate," the agency said in the safety announcement.

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