Cancer Risk Higher Among Japanese with Diabetes

Men especially at risk for cancer of liver, pancreas and kidneys

MONDAY, Sept. 25 (HealthDay News) -- Japanese adults with diabetes mellitus, particularly men, are at increased risk of cancer, notably of the liver, pancreas and kidneys, according to the results of a study published in the Sept. 25 issue of the Archives of Internal Medicine.

Manami Inoue, M.D., Ph.D., of the National Cancer Center in Tokyo, Japan, and colleagues conducted a study among 97,771 adults in the general population, comprising 46,548 men and 51,223 women aged 40 to 69. They were enrolled in the Japan Public Health Center-Based Prospective Study from 1990 to 1994 and were followed up until the end of 2003 for cancer incidence.

During the course of the study there were 6,462 cases of newly diagnosed cancer, and among men with diabetes mellitus there was a 27 percent higher incidence of total cancers, with an especially high hazard ratio for liver, pancreas and kidney cancer. There was also a moderate increase among those with diabetes mellitus in incidence of colon cancer and stomach cancer, although the latter was of borderline significance.

Among women, the impact of diabetes mellitus on cancer risk was less pronounced, and was only of statistical significance for stomach and liver cancers.

"The remarkable increase in the diagnosis of diabetes mellitus in Japan in recent years may affect future trends in the incidence and type of cancer," the authors conclude.

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