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Meta-Analysis: Risk of Dementia Up in Type 2 Diabetes

Greater additional risk for women with diabetes for vascular, but not nonvascular, dementia

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FRIDAY, Dec. 18, 2015 (HealthDay News) -- The risk of dementia is increased for individuals with type 2 diabetes, and the additional risk of vascular dementia, but not nonvascular dementia, is greater in women than in men, according to a meta-analysis published online Dec. 17 in Diabetes Care.

Saion Chatterjee, from Alfred Health in Melbourne, Australia, and colleagues conducted a meta-analysis to examine the sex-specific relationship between women and men with diabetes and incident dementia. Data were included from 14 studies, with 2,310,330 individuals and 102,174 dementia case patients.

The researchers found that diabetes correlated with an increased risk of any dementia in both sexes (women: pooled relative risk [RR], 1.62; men: pooled RR, 1.58), in multiple-adjusted analyses. For vascular dementia, the diabetes-associated RRs were 2.34 in women and 1.73 in men; the corresponding RRs were 1.53 and 1.49 for nonvascular dementia. Compared with men, women with diabetes had an increased risk for the development of vascular dementia (multiple-adjusted ratio of RRs, 1.19; P < 0.001).

"Individuals with type 2 diabetes are at ~60 percent greater risk for the development of dementia compared with those without diabetes," the authors write. "For vascular dementia, but not for nonvascular dementia, the additional risk is greater in women."

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