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Fiber Intake Linked to Adiponectin in Diabetic Women

May help improve insulin sensitivity and serum lipid profiles

WEDNESDAY, July 12 (HealthDay News) -- Dietary cereal fiber intake and glycemic load are associated with circulating levels of the adipose-secreted cytokine, adiponectin, according to a report in the July issue of Diabetes Care. Higher adiponectin levels have been previously associated with reduced risk for diabetes and cardiovascular disease.

Lu Qi, M.D., Ph.D., from Harvard School of Public Health in Boston, and colleagues used data from the Nurses' Health Study to examine the association of dietary fiber and glycemic load with adiponectin levels in 902 women with type 2 diabetes.

After multiple adjustments, cereal and fruit fiber intake was positively associated with plasma adiponectin concentrations and was not modified by obesity status. Adiponectin levels were 24 percent higher in the highest quintile of fiber intake compared with the lowest. Glycemic load and glycemic index showed an opposite effect on adiponectin concentrations, with extreme quintiles showing a 17 percent and 18 percent difference in adiponectin levels, respectively.

"We found that intake of cereal fiber was associated with higher adiponectin concentrations in diabetic women," the authors write. "The results, together with our earlier findings in diabetic men, strongly indicate that dietary cereal fiber and glycemic load/index may be important determinants for the blood concentrations of adiponectin in patients with type 2 diabetes."

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