Fructose-Rich Corn Syrup Intake Raises CVD Risk

Increase in triglycerides, LDL, apolipoprotein B with fructose, high-fructose corn syrup intake

THURSDAY, Aug. 18 (HealthDay News) -- Consuming high-fructose corn syrup (HFCS) for two weeks at 25 percent of energy requirements (E) increases triglycerides, low-density lipoprotein (LDL), and apolipoprotein B (apoB) levels in young adults comparably to fructose but more than glucose, according to a study published online Aug. 17 in the Journal of Clinical Endocrinology & Metabolism.

Kimber L. Stanhope, Ph.D., from the University of California in Davis, and colleagues compared the effects of glucose, fructose, and HFCS consumption at 25 percent of E on cardiovascular disease risk factors. Inpatient baseline testing was performed in 48 adults between the ages of 18 and 40 years with a body mass index between 18 and 35 kg/m² after consuming energy-balanced diets containing 55 percent-E complex carbohydrate for 3.5 days. Then, for 12 outpatient days, participants consumed three servings a day of either glucose, fructose, or HFCS-sweetened beverages providing 25 percent of E, along with their usual ad libitum diets. Afterward, during 3.5 days of inpatient testing, they consumed energy-balanced diets containing 25 percent-E sugar-sweetened beverages or 30 percent-E complex carbohydrate. The main outcome measures were 24 hour triglyceride area under the curve (24-h TG AUC), fasting plasma LDL, and apoB concentrations.

The investigators found that, compared to baseline measurements, 24-h TG AUC significantly increased with fructose and HFCS consumption but not with glucose. Fasting LDL and apoB concentrations also significantly increased during fructose and HFCS consumption but not glucose.

"Consumption of HFCS-sweetened beverages for two weeks at 25 percent [of] E increased risk factors for cardiovascular disease comparably to fructose and more than glucose in young adults," the authors write.

Several authors disclosed financial ties to the pharmaceutical industry.

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