Polycarbonate Drinking Bottles Release Bisphenol A

At room temperature, bottles release neurotoxic amounts of the endocrine disrupting chemical

WEDNESDAY, Jan. 30 (HealthDay News) -- Even at room temperature, polycarbonate drinking bottles release the endocrine disrupting chemical bisphenol A in amounts that mimic the neurotoxic effects of estrogen in developing cerebellar neurons, researchers report in the Jan. 30 issue of Toxicology Letters.

Hoa H. Le, of the University of Cincinnati College of Medicine in Cincinnati, Ohio, and colleagues studied the migration of bisphenol A into room-temperature water in new and used polycarbonate drinking bottles. They also studied the migration of bisphenol A in drinking bottles filled with boiling water.

Using a sensitive and quantitative competitive enzyme-linked immunosorbent assay, the researchers found that bisphenol A was released into room-temperature water at rates of 0.20-0.79 ng per hour in both new and used bottles. They also found that bottles filled with boiling water released bisphenol A at rates up to 55 times greater. The investigators used an in vitro assay of rapid estrogen signaling and neurotoxicity in developing cerebellar neurons to confirm the estrogenic effects of the released bisphenol A.

"It is now clear that conclusions from single-compound studies, or association of health risks with a single endocrine disrupting chemical, may not fully reflect the effects of environmental exposures to endocrine disrupting chemicals," the authors write. "Thus, the contribution of the concentrations of bisphenol A that contaminate drinking water and foods stored in polycarbonate bottles should be considered as a single, though important component of the total mixture of endocrine disrupting chemicals to which humans are acutely and chronically exposed throughout their lifetime."

Abstract
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