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Higher Vitamin K Intake May Reduce Risk of Diabetes

Both phylloquinone and menaquinones appear to be associated with a decreased risk

MONDAY, Aug. 2 (HealthDay News) -- Higher intake of the biologically active forms of vitamin K, phylloquinone and menaquinones, may reduce the risk of type 2 diabetes, according to research published in the August issue of Diabetes Care.

Joline W.J. Beulens, Ph.D., of the University Medical Center Utrecht in the Netherlands, and colleagues evaluated data from a prospective cohort study of 38,094 Dutch adults to evaluate the effect of dietary phylloquinone and menaquinones on the risk of type 2 diabetes. Phylloquinone and menaquinones intake was assessed by means of a validated food frequency questionnaire, and the follow-up period was 10.3 years.

The researchers found that phylloquinone intake had a tendency to be associated with a decreased risk of diabetes for the highest tertile of intake compared to the lowest tertile (hazard ratio, 0.81; P = 0.08). A linear, inverse association was found for menaquinones intake (P = 0.038), with a 7 percent decreased risk of type 2 diabetes for each 10-µg increment increase in intake.

"In summary, the findings of this study show that both phylloquinone and menaquinones intakes may be associated with a reduced risk of type 2 diabetes. For phylloquinone intake, these risk reductions occurred at higher levels of intake, whereas for menaquinones a linear, inverse association was observed," the authors write.

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