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HIV Infection Linked to More Fractures

Higher prevalence of fractures at multiple sites

FRIDAY, Sept. 5 (HealthDay News) -- HIV-infected patients have a higher prevalence of fracture at multiple sites compared with non-infected individuals, according to research published in the September issue of the Journal of Clinical Endocrinology & Metabolism.

Virginia A. Triant, M.D., from Massachusetts General Hospital in Boston, and colleagues compared the prevalence of fracture in 8,525 HIV-infected and 2,208,792 non-HIV-infected patients seen by a doctor between 1996 and 2008.

The researchers found a significantly higher fracture prevalence in HIV-infected patients (2.87 versus 1.77 per 100 persons). Compared with non-HIV-infected females, females with HIV had a significantly higher prevalence of vertebral and wrist fractures, but a similar prevalence of hip fractures. Compared with non-HIV-infected males, males with HIV had a significantly higher prevalence of vertebral, hip and wrist fractures, the investigators report. Fracture prevalence was higher among HIV-infected blacks and whites, compared to non-infected blacks and whites, the report indicates.

"This study suggests the importance of assessing bone density and minimizing factors contributing to increased fracture risk in the HIV-infected population," the authors conclude.

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