Genetic Risk Score Associated With Diabetes Prediction
Risk based on alleles expressed at 34 loci known to be associated with type 2 diabetes
FRIDAY, April 8 (HealthDay News) -- A high genetic risk score (GRS) based on the specific alleles expressed at 34 loci is associated with an increased risk of diabetes in high-risk individuals, according to a study published in the April issue of Diabetes.
Marie-France Hivert, M.D, from Université de Sherbrooke in Canada, and colleagues examined the predictive ability of a GRS based on 34 genetic loci associated with type 2 diabetes in a cohort of 2,843 participants of the Diabetes Prevention Program (DPP) at high risk of type 2 diabetes. Participants were genotyped, and a GRS was built by evaluating the relative risk of each allele. The ability to predict diabetes incident, or regression to normal glucose regulation (NGR), was evaluated after adjusting for confounders.
The investigators found that the GRS was significantly correlated with raised risk of progression to diabetes (hazard ratio [HR], 1.02 per risk allele). There was also a significant association between the GRS and reduced likelihood of regression to NGR (HR, 0.95 per risk allele). A higher GRS at baseline was significantly correlated with lower insulinogenic index. There was no significant association between GRS and treatment, but lifestyle intervention was effective for those participants in the highest quartile of GRS.
"We demonstrated that a higher type 2 diabetes genetic risk estimated with a score built from 34 known type 2 diabetes loci is associated with a greater likelihood of progressing toward diabetes and a lower likelihood of regressing to NGR in DPP participants," the authors write.
Several authors disclosed financial ties with pharmaceutical companies.