Type 2 Diabetes Susceptibility Alleles Tied to BMI in Children

Associated with lower body mass index in 8-year-olds born large for gestational age

THURSDAY, Aug. 26 (HealthDay News) -- In children who were born large for gestational age, certain type 2 diabetes susceptibility alleles are linked to low body mass index (BMI) at age 8, according to research published in the August issue of Diabetes.

Christiane Winkler, Ph.D., of the Helmholtz Center Munich in Neuherberg, Germany, and colleagues analyzed data from 646 children of mothers or fathers with type 1 diabetes. Children underwent assessment of BMI, weight, and height at age 8, along with single-nucleotide polymorphism genotyping of loci in the type 2 diabetes susceptibility genes HHEX-IDE and CDKAL1.

The researchers found that, after stratification for birth weight, HHEX-IDE and CDKAL1 risk alleles were associated with reduced BMI expressed as standard deviation scores (BMI-SDS) and weight-SDS in children who were born large for gestational age. This finding was not seen in children who were born small or appropriate for gestational age. Among children born large for gestational age, each additional type 2 diabetes risk allele was associated with decreasing BMI and weight.

"In conclusion, we show that the fetal programming associated with the type 2 diabetes susceptibility genes HHEX-IDE and CDKAL1 has prolonged effects during childhood as evidenced by the influence of birth weight status on BMI and weight at age 8 years, and that further programming in association with these genes occurs during childhood when there has been excess fetal growth," the authors write.

Abstract
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