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Elevation of Serum Uric Acid Level Associated With Diabetes

Untreated hypertensive patients with increased serum uric acid level more likely to develop diabetes

FRIDAY, Jan. 21 (HealthDay News) -- Elevation of serum uric acid (SUA) levels is associated with an increased risk of developing new-onset diabetes in hypertensive patients, according to results from a study published in the January issue of Diabetes Care.

Francesca Viazzi, M.D., from the University of Genoa in Italy, and colleagues evaluated data from a prospective, observational study of 758 patients with untreated hypertension (MAGIC study). Patients did not suffer from diabetes or cardiovascular disease at the baseline observation and were observed for a median of 11 years.

Follow-up was based on a total of 8,332 person-years and showed that a slight baseline elevation in SUA levels was associated with an increased risk of developing diabetes. An increased risk was found when SUA levels were at or greater than 318 µmol/l for women (hazard ratio [HR], 5.85), or 420 µmol/l for men (HR, 2.86). The overall HR for developing diabetes was 3.65 (P < 0.0001). After adjusting for confounding factors including age, sex, and metabolic syndrome, the HR was 2.78 (P = 0.0054).

"The present study shows that over long-term follow-up, SUA is a powerful predictor of incident type 2 diabetes in primary hypertension, especially in women," the authors write.

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