Platelets Play Role in Corpus Luteum Formation

Platelet-derived soluble factors induce migration of endothelial cells

FRIDAY, July 13 (HealthDay News) -- Platelets regulate neovascularization and luteinization during human corpus luteum formation, and platelet-derived soluble factors induce the migration of endothelial cells, according to a study in the July issue of Endocrinology.

Hiroshi Fujiwara, M.D., from Kyoto University in Japan, and colleagues examined the role of platelets during early tissue remodeling of the corpus luteum.

The researchers found that red blood cells and platelets were deposited at extravascular sites among luteinizing granulosa cells, with platelet levels gradually decreasing near the central cavity towards which microvessels were extending. Platelets also increase progesterone production by luteinizing granulosa cells. Soluble factors produced by platelets induced granulosa cell spreading and migration of human umbilical vein endothelial cells.

The study suggests that "platelets are regulators of endothelial cell migration and granulosa cell luteinization in the remodeling process of the human corpus luteum," Fujiwara and colleagues conclude.

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