Plasma Enzyme Essential for Successful Reproduction

Phospholipase C-β1 affects reproductive behavior, ovulation, and implantation

MONDAY, June 29 (HealthDay News) -- The plasma enzyme phospholipase C-β1 may be essential for reproduction, according to a study published in the July issue of Endocrinology.

Panayiotis Filis, a post-graduate student at the University of Edinburgh in the United Kingdom, and colleagues studied male and female mice that lacked functional phospholipase C-β1.

The researchers found that the males and females had impaired reproductive behavior. Although they observed no other reproductive defects in the males, they found that females exhibited defective ovulation, early embryonic development, and an implantation defect characterized by poor embryo attachment and a failure to up-regulate cyclooxygenase-2 mRNA.

"The data signify that G protein-linked cell surface receptor activation of phospholipase C-β1 plays important roles in controlling reproductive success," the authors conclude.

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