See What HealthDay Can Do For You
Contact Us

Effects of n-3 PUFAs on Insulin Sensitivity Unclear

No effect on peripheral insulin sensitivity; modest improvement in hepatic insulin sensitivity

TUESDAY, April 14, 2015 (HealthDay News) -- Dietary n-3 polyunsaturated fatty acids (PUFAs), including eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), do not appear to have clinically meaningful effects on peripheral or hepatic insulin sensitivity in insulin-resistant adults without diabetes, according to research published online April 7 in Diabetes Care.

Antigoni Z. Lalia, M.D., of the Mayo Clinic College of Medicine in Rochester, Minn., and colleagues conducted a randomized, double-blind study in which 31 insulin-resistant adults, without diabetes, received either 3.9 g/day EPA+DHA or placebo for six months. A hyperinsulinemic-euglycemic clamp with somatostatin was used to assess hepatic and peripheral insulin sensitivity. Insulin secretion and muscle mitochondrial function were also evaluated.

The researchers found that, compared with placebo, EPA+DHA did not affect peripheral insulin sensitivity, postprandial glucose disposal, or insulin secretion. A small, but significant, improvement in hepatic insulin sensitivity, determined from the suppression of endogenous glucose production by insulin, was observed for EPA+DHA compared with placebo. Neither EPA+DHA nor placebo influenced muscle mitochondrial function.

"This study demonstrates that dietary EPA+DHA does not improve peripheral glucose disposal, insulin secretion, or skeletal muscle mitochondrial function in insulin-resistant nondiabetic humans," the authors write. "There was a modest improvement in hepatic insulin sensitivity with EPA+DHA, but this was not associated with any improvements in clinically meaningful outcomes."

One author is a member of the Scientific Advisory Board of Sancilio and Company, which supplied materials for the study.

Full Text (subscription or payment may be required)

Physician's Briefing


HealthDay is the world’s largest syndicator of health news and content, and providers of custom health/medical content.

Consumer Health News

A health news feed, reviewing the latest and most topical health stories.

Professional News

A news feed for Health Care Professionals (HCPs), reviewing latest medical research and approvals.