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ENDO: Older Men Benefit From Testosterone Supplementation

Significant declines observed in metabolic syndrome, C-reactive protein, and liver enzymes

MONDAY, June 15 (HealthDay News) -- In middle-aged and older men with low testosterone levels, testosterone supplementation may improve signs of metabolic syndrome and other health measures, according to a study presented at the Endocrine Society's 91st Annual Meeting, held from June 10 to 13 in Washington, D.C.

Farid Saad, Ph.D., of Bayer Schering Pharma AG in Berlin, and a colleague studied 122 men ages 36 to 69 years who were treated for 24 to 30 months with parenteral testosterone undecanoate.

After six months, the researchers found that testosterone supplementation was associated with significant declines in body mass index, waist circumference, and low-density lipoprotein cholesterol, and with significant increases in high-density lipoprotein cholesterol. They also found that the therapy was associated with a steady decline in levels of C-reactive protein and liver enzymes.

"Restoring plasma testosterone levels to normal in elderly hypogonadal men leads to significant improvements of features of the metabolic syndrome and of liver steatosis," the authors conclude. "Part of the improvements are progressive over time."

Abstract No. P3-308 (login may be required)
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