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American Diabetes Association, June 21-25, 2013

The American Diabetes Association's 73rd Scientific Sessions

The annual meeting of the American Diabetes Association was held from June 21 to 25 in Chicago and attracted approximately 13,000 participants from around the world, including clinicians, academicians, allied health professionals, and others interested in diabetes. The conference highlighted the latest advances in diabetes research and improving patient care, with presentations focusing on treatment recommendations and advances toward a cure for diabetes.

In one study, Jill R. Landsbaugh, Ph.D., of the University of Colorado in Denver, and colleagues found that adequate control of gestational weight gain may reduce the negative effects of maternal overweight/obesity on metabolic outcomes in offspring.

"Women who had a body mass index (BMI) of 25 kg/m² or greater were more likely to exceed the Institute of Medicine (IOM) recommendations for weight gain compared to women who began their pregnancy at a healthy weight (gestational weight gain recommendations: 11 to 25 pounds for women with a BMI of 25 kg/m² or greater (overweight/obese), 25 to 35 pounds for women with a BMI of less than 25 kg/m² (healthy BMI)," said Landsbaugh.

The investigators also found that the "worse metabolic risk factors" in the offspring go away for the overweight/obese women who stay within the IOM recommendations (gain of 11 to 25 pounds).

"It is key that physicians are aware of the IOM recommendations for weight gain. Physicians need to make sure they inform their patients of these guidelines and make sure they know that they need to stay within the recommendations," Landsbaugh added. "To do the best for their offspring, these women need to be aware of the guidelines and work to ensure they do not exceed them. By maintaining a healthy weight gain throughout pregnancy, these mothers will then help their offspring by decreasing their risk for the negative consequences of obesity, diabetes, and other metabolic disorders."

Abstract No. 76-OR

In another study, Pengcheng Xun, M.D., Ph.D., of Indiana University in Bloomington, and colleagues observed a threshold association between cadmium exposure and diabetes risk in American young adults.

"The risk of incident diabetes significantly increased by 43, 54, 51, and 59 percent from the second to the fifth quintiles as compared to quintile one. After dichotomizing cadmium exposure by grouping quintile two through five, the risk of diabetes increased about 50 percent when comparing to quintile one," said Xun. "Since clinical trial is not applicable, further prospective cohort studies in other populations are warranted to confirm our findings."

Abstract No. 83-OR

Kasia J. Lipska, M.D., of Yale University in New Haven, Conn., and colleagues found a marked reduction in admissions for hyperglycemia; however, hypoglycemia continues to be a problem during a time when glycemic control has improved in the United States.

"In our national study of Medicare patients, rates of admissions for hypoglycemia exceed those for hyperglycemia. From 1999 to 2011, there was a clear decline in admissions for hyperglycemia (by 39 percent), but we have not made similar progress in hypoglycemia. In fact, rates of admissions increased from 1999 to 2007, then modestly declined," said Lipska. "We found striking disparities, with rates among black patients four-fold higher compared with white patients for both complications. Rates for hypoglycemia were two-fold higher among older compared with younger Medicare beneficiaries."

Abstract No. 274-OR

ADA: Lifestyle Changes Have No Lasting Benefit in T2DM

TUESDAY, June 25 (HealthDay News) -- For patients with type 2 diabetes, an intensive lifestyle intervention consisting of diet and exercise is not associated with a decrease in cardiovascular events in long-term follow-up, according to a study published online June 24 in the New England Journal of Medicine to coincide with presentation at the annual meeting of the American Diabetes Association, held from June 21 to 25 in Chicago.

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ADA: Insulin-Pump Tx With Threshold-Suspend Beneficial

MONDAY, June 24 (HealthDay News) -- For patients with type 1 diabetes and documented nocturnal hypoglycemia, insulin-pump therapy with a threshold-suspend feature reduces nocturnal hypoglycemia over a three-month period, according to a study published online June 22 in the New England Journal of Medicine to coincide with presentation at the annual meeting of the American Diabetes Association, held from June 21 to 25 in Chicago.

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