December 2012 Briefing - Diabetes & Endocrinology

Here are what the editors at HealthDay consider to be the most important developments in Diabetes & Endocrinology for December 2012. This roundup includes the latest research news from journal articles, as well as the FDA approvals and regulatory changes that are the most likely to affect clinical practice.

Little Change in Global Infertility Rates Since 1990

MONDAY, Dec. 31 (HealthDay News) -- Infertility rates worldwide are similar to those in 1990, though the number of couples affected by infertility rose to nearly 50 million in 2010 due to population growth, according to a study published online Dec. 18 in PLOS Medicine.

Abstract
Full Text

Primary Care Physicians Perform Well on Diabetes Care Measures

FRIDAY, Dec. 28 (HealthDay News) -- Compared to covering physicians or midlevel providers, primary care physicians (PCPs) perform better on multiple critical process measures for diabetes care, according to a study published online Dec. 10 in Diabetes Care.

Abstract
Full Text (subscription or payment may be required)

Low Insulin Secretion Tied to Depressive Symptoms in Women

FRIDAY, Dec. 28 (HealthDay News) -- Middle-aged women with insulin secretion levels in the lowest quintile appear to have more than twice the risk of developing new-onset depressive symptoms compared with those with higher insulin secretion levels, according to research published online Dec. 10 in Diabetes Care.

Abstract
Full Text (subscription or payment may be required)

Dietary PA/OA Fat Ratio May Affect T2DM Risk in Women Only

FRIDAY, Dec. 28 (HealthDay News) -- A diet low in palmitic acid (PA) and high in oleic acid (OA) improves insulin sensitivity and is associated with lower levels of markers of metabolic and oxidative stress in women only, according to a study published online Dec. 13 in Diabetes.

Abstract
Full Text (subscription or payment may be required)

Teen Vitamin D Intake Not Related to Adult RA or SLE Risk

THURSDAY, Dec. 27 (HealthDay News) -- Dietary vitamin D intake during adolescence does not appear to be associated with the risk of adult-onset rheumatoid arthritis (RA) or systemic lupus erythematosus (SLE), according to research published in the December issue of Arthritis Care & Research.

Abstract
Full Text (subscription or payment may be required)

Indicators Show Little Change in Overuse of Ambulatory Care

THURSDAY, Dec. 27 (HealthDay News) -- In the United States from 1999 to 2009, the delivery of underused care in the ambulatory setting improved, but fewer changes were seen in inappropriate care, according to a study published online Dec. 24 in the Archives of Internal Medicine.

Abstract
Full Text (subscription or payment may be required)
Editorial (subscription or payment may be required)

Early Menopause Tied to Greater Type 2 Diabetes Risk

THURSDAY, Dec. 27 (HealthDay News) -- Women who experience early menopause have a greater risk of type 2 diabetes, according to a study published online Dec. 10 in Diabetes Care.

Abstract
Full Text (subscription or payment may be required)

Fewer Than a Quarter Call 911 During Acute Heart Problem

THURSDAY, Dec. 27 (HealthDay News) -- During acute coronary syndromes, fewer than one-quarter of patients call 911, according to a study published in the Jan. 1 issue of The American Journal of Cardiology.

Abstract
Full Text (subscription or payment may be required)

C-Peptide Levels May Predict Mortality in Angiography Patients

WEDNESDAY, Dec. 26 (HealthDay News) -- Higher levels of C-peptide, a pro-insulin cleavage product, is associated with all-cause and cardiovascular mortality in patients undergoing coronary angiography, according to a study published online Nov. 30 in Diabetes Care.

Abstract
Full Text (subscription or payment may be required)

Standards of Medical Care in Diabetes Released for 2013

FRIDAY, Dec. 21 (HealthDay News) -- Updated evidence for diabetes care, including guidelines for self-monitoring glucose, new blood pressure targets, and other aspects of care, are presented in a major position statement from the American Diabetes Association (ADA), "Standards of Medical Care in Diabetes," published as a supplement to the January issue of Diabetes Care.

More Information

Motor Vehicle Incidents Common in Medical Residents

FRIDAY, Dec. 21 (HealthDay News) -- During training, internal medicine residents commonly experience motor vehicle incidents, including crashes and near misses, but less commonly experience blood and body fluid (BBF) exposures, according to research published in the December issue of the Mayo Clinic Proceedings.

Abstract
Full Text (subscription or payment may be required)

Metformin Treatment Beneficial for Obese Children, Teens

THURSDAY, Dec. 20 (HealthDay News) -- Obese children and adolescents treated with twice-daily metformin have significantly improved body mass index standard deviation scores (BMI-SDS), fasting glucose, and other metabolic risk factors, according to research published online Nov. 21 in the Journal of Clinical Endocrinology & Metabolism.

Abstract
Full Text (subscription or payment may be required)

Meds Adherence Self-Report Valid in Type 2 Diabetes

THURSDAY, Dec. 20 (HealthDay News) -- Self-reported measures of medication adherence in adults with type 2 diabetes are valid, although some self-reports are moderated by depression, according to a study published online Nov. 30 in Diabetes Care.

Abstract
Full Text (subscription or payment may be required)

Paroxetine Protects Endothelial Cells From Hyperglycemia

WEDNESDAY, Dec. 19 (HealthDay News) -- The antidepressant paroxetine protects endothelial cells against hyperglycemia-induced injury, including reactive oxygen species (ROS) formation, according to a study published online Dec. 7 in Diabetes.

Abstract
Full Text (subscription or payment may be required)

Many Docs Use Social Media to Find, Share Medical Data

WEDNESDAY, Dec. 19 (HealthDay News) -- Most physicians use social media on at least a weekly basis, and report that it improves the quality of patient care they deliver, according to a study published in the September/October issue of the Journal of Medical Internet Research.

Full Text

Two Distinct High-Risk Diabetes Populations ID'd in Children

TUESDAY, Dec. 18 (HealthDay News) -- Children with high-risk A1C (hrA1C) and impaired fasting glucose (IFG) define different populations, with differentially increased risk markers, according to research published online Nov. 27 in Diabetes Care.

Abstract
Full Text (subscription or payment may be required)

Intensive Lifestyle Changes Do Raise Odds of T2DM Remission

TUESDAY, Dec. 18 (HealthDay News) -- For overweight adults, an intensive lifestyle intervention (ILI) is associated with a greater likelihood of remission compared with diabetes support and education (DSE), although the absolute remission rates are modest, according to a study published in the Dec. 19 issue of the Journal of the American Medical Association.

Abstract
Full Text (subscription or payment may be required)
Editorial (subscription or payment may be required)

Significant, Complex Link ID'd Between Sleepiness, Vitamin D

TUESDAY, Dec. 18 (HealthDay News) -- There is a significant correlation between 25-hydroxyvitamin D (25[OH]D) and sleepiness, which is affected by race for individuals with vitamin D deficiency (VitDd; defined as 25(OH)D <20 ng/mL), according to research published in the December issue of the Journal of Clinical Sleep Medicine.

Abstract
Full Text (subscription or payment may be required)

Aerobic Exercise Optimal for Reducing Fat Mass, Body Mass

TUESDAY, Dec. 18 (HealthDay News) -- For sedentary, overweight, or obese adults, aerobic training (AT) seems to be the optimal mode of exercise for reducing fat mass and body mass, while a combined approach of AT and resistance training (RT) increases the time commitment with no added loss compared with AT alone, according to a study published in the Dec. 15 issue of the Journal of Applied Physiology.

Abstract
Full Text (subscription or payment may be required)

Signifor Approved for Cushing's Disease

MONDAY, Dec. 17 (HealthDay News) -- Signifor (pasireotide diaspartate) has been approved by the U.S. Food and Drug Administration to treat Cushing's disease in cases that cannot be treated by surgery.

More Information

Health Care Satisfaction Rated As High by Unacculturated Hispanics

MONDAY, Dec. 17 (HealthDay News) -- Hispanic patients, particularly unacculturated Hispanics, rate their health care experience more highly than do other patient groups, according to a study published in the October issue of the Journal of Immigrant and Minority Health.

Abstract
Full Text (subscription or payment may be required)

Dietary Fat Increases Glucose Level and Insulin Needs

MONDAY, Dec. 17 (HealthDay News) -- A high-fat meal increases the postprandial glucose levels and insulin requirements of patients with type 1 diabetes, according to research published online Nov. 27 in Diabetes Care.

Abstract
Full Text (subscription or payment may be required)

Leisure-Time Physical Activity Could Add Up to Five Years to Life

FRIDAY, Dec. 14 (HealthDay News) -- Leisure-time physical activity is associated with an increased life expectancy of up to 5.5 years, according to a study published online Dec. 11 in the American Journal of Preventive Medicine.

Full Text

Life Expectancy Up But More Healthy Years Lost to Disability

FRIDAY, Dec. 14 (HealthDay News) -- Although life expectancy is increasing, global estimates of healthy life expectancy indicate that the world's population loses more years of healthy life to disability today than in the past, according to the Global Burden of Disease Study 2010, published in the Dec. 15 special issue of The Lancet.

More Information

Imeglimin Beneficial As Add-On to Metformin in T2DM

THURSDAY, Dec. 13 (HealthDay News) -- For patients with type 2 diabetes inadequately controlled by metformin alone, addition of the new oral anti-diabetes agent imeglimin improves glycemic control with good tolerability and safety, according to a study published online Nov. 16 in Diabetes Care.

Abstract
Full Text (subscription or payment may be required)

Exercise Performance Enhanced With Virtual Partner

THURSDAY, Dec. 13 (HealthDay News) -- Exercise duration is improved by exercising with a virtual partner, especially with a moderately superior partner, according to a study published in the October issue of the Annals of Behavioral Medicine.

Abstract
Full Text

Raising Taxes on Sugars, Fats May Be Viable Health Strategy

THURSDAY, Dec. 13 (HealthDay News) -- Taxes on sugar and saturated fats could be associated with beneficial dietary change, according to a study published online Dec. 11 in PLOS Medicine.

Abstract
Full Text (subscription or payment may be required)

Increased Risk of Diabetes for Breast Cancer Survivors

THURSDAY, Dec. 13 (HealthDay News) -- Postmenopausal women with breast cancer have an increased risk of developing diabetes, which varies over time, according to a study published online Dec. 12 in Diabetologia.

Abstract
Full Text (subscription or payment may be required)

Current Health Costs Pushing Docs to Make Urgent Choices

WEDNESDAY, Dec. 12 (HealthDay News) -- The current growth in health care's share of the gross domestic product (GDP) and need to implement learning health systems is forcing physicians to make important choices, according to a perspective piece published online Dec. 12 in the New England Journal of Medicine.

Full Text

Prevalence of Nonrefractive Visual Impairment Increasing

TUESDAY, Dec. 11 (HealthDay News) -- From 1999-2002 to 2005-2008, there has been an increase in the prevalence of nonrefractive visual impairment, which may be partly due to the increasing prevalence of diabetes, specifically long-duration diabetes, according to research published in the Dec. 12 issue of the Journal of American Medical Association.

Abstract
Full Text (subscription or payment may be required)
Editorial (subscription or payment may be required)

NHANES Data Don't Support BPA, Chronic Disease Link

TUESDAY, Dec. 11 (HealthDay News) -- An analysis of data from a public health database has shown no association between urinary bisphenol A (BPA) levels and chronic diseases, unlike previous studies, but this dataset may be inappropriate to analyze such associations, according to research published online Dec. 5 in PLOS One.

Abstract
Full Text

Mindfulness-Based Cognitive Therapy Beneficial in Diabetes

TUESDAY, Dec. 11 (HealthDay News) -- For patients with diabetes and low levels of emotional well-being, mindfulness-based cognitive therapy (MBCT) improves emotional distress and health-related quality of life, according to a study published online Nov. 27 in Diabetes Care.

Abstract
Full Text (subscription or payment may be required)

Maternal BMI Negatively Linked to Child Cognition

MONDAY, Dec. 10 (HealthDay News) -- Maternal pre-pregnancy body mass index (BMI) is negatively associated with children's cognitive performance at ages 5 and 7, although the overall effect size is modest, according to research published online Dec. 10 in Pediatrics.

Abstract
Full Text (subscription or payment may be required)

Number of Independent Physicians Continues to Decline

MONDAY, Dec. 10 (HealthDay News) -- Physician business models are transforming, with a sustained shift away from independent practice, according to report released by the consulting firm Accenture.

More Information

Gene-Environment Interaction Ups Risk of Preeclampsia

MONDAY, Dec. 10 (HealthDay News) -- A genetic variant, AGT2R, in mothers, fathers, and neonates is associated with a significantly increased risk of preeclampsia in mothers with a body mass index (BMI) of 25 kg/m² or more, according to a study published online Nov. 5 in Placenta.

Abstract
Full Text (subscription or payment may be required)

EHR Algorithm Can Be Used to Detect, Classify Diabetes

MONDAY, Dec. 10 (HealthDay News) -- Data from electronic health records (EHRs) can be used to detect more cases of diabetes than claim codes alone and can be used to accurately distinguish between type 1 and type 2 diabetes, according to a study published online Nov. 27 in Diabetes Care.

Abstract
Full Text (subscription or payment may be required)

Anticompetitive Market Power Common in Managed Care Plans

FRIDAY, Dec. 7 (HealthDay News) -- For each of the three most popular types of managed care plans in the United States (point-of-service plan [POS], health maintenance organization [HMO], and preferred provider organization [PPO]), anticompetitive market power is widespread, according to a Nov. 28 news release from the American Medical Association (AMA).

More Information

Health Care Law Boosts Savings on Meds for Medicare Recipients

FRIDAY, Dec. 7 (HealthDay News) -- Savings on prescription drugs related to the Affordable Care Act have reached $5.1 billion, according to a Dec. 3 news release from the U.S. Department of Health and Human Services.

More Information

Low Testosterone Levels Affect Total Lipid Oxidation

THURSDAY, Dec. 6 (HealthDay News) -- Very low testosterone levels impact total lipid oxidation but have no effect on the production of very-low-density lipoprotein-triglycerides (VLDL-TGs), according to a study published online Nov. 27 in Diabetes.

Abstract
Full Text (subscription or payment may be required)

FDA: Public-Private Venture Set to Improve Regulatory Science

THURSDAY, Dec. 6 (HealthDay News) -- The Medical Device Innovation Consortium (MDIC), the first public-private partnership to promote medical device regulatory science, has been established, according to a Dec. 3 news release issued by the U.S. Food and Drug Administration.

More Information

Resistance Exercise Offers More Prolonged Glycemic Control

WEDNESDAY, Dec. 5 (HealthDay News) -- For patients with type 1 diabetes, resistance exercise is associated with a smaller initial decline in blood glucose compared with aerobic exercise, but offers a more prolonged reduction in post-exercise glycemia, according to research published online Nov. 19 in Diabetes Care.

Abstract
Full Text (subscription or payment may be required)

Five-Hour Protected Sleep Feasible for Medical Interns

TUESDAY, Dec. 4 (HealthDay News) -- Implementation of a five-hour period of protected sleep is feasible for medical interns on long shifts, resulting in interns getting more uninterrupted sleep and feeling more alert the next day, according to a study published in the Dec. 5 issue of the Journal of the American Medical Association.

Abstract
Full Text (subscription or payment may be required)

Few Internal Medicine Residents Choosing Primary Care

TUESDAY, Dec. 4 (HealthDay News) -- Only about one in five graduating internal medicine residents in the United States plan to enter general internal medicine (GIM), which is more common among graduates of primary care programs, women, and U.S. medical graduates, according to a study published in the Dec. 5 issue of the Journal of the American Medical Association.

Abstract
Full Text (subscription or payment may be required)

Mimetic Antibody Shows Potential Metabolic Benefits

TUESDAY, Dec. 4 (HealthDay News) -- A new engineered monoclonal antibody, mimAb1, can activate fibroblast growth factor 21 (FGF21)-like metabolic effects via the FGF21-FGF receptor 1c (FGFR1c) receptor complex in an obese monkey model, according to a study published online Nov. 28 in Science Translational Medicine.

Abstract
Full Text (subscription or payment may be required)

Intravitreal Pegaptanib Useful in Diabetic Macular Edema

MONDAY, Dec. 3 (HealthDay News) -- For patients with diabetes with clinically significant macular edema (CME), treatment with intravitreal pegaptanib sodium (Macugen), which selectively inhibits vascular endothelial growth factor-165 isoforms, is associated with significant morphological and functional changes, according to a study published in the December issue of the British Journal of Clinical Pharmacology.

Abstract
Full Text (subscription or payment may be required)

High Fructose Corn Syrup Availability Linked to Diabetes

MONDAY, Dec. 3 (HealthDay News) -- Countries with a higher availability of high fructose corn syrup (HFCS) have a higher prevalence of type 2 diabetes, according to a study published online Nov. 27 in Global Public Health.

Abstract
Full Text (subscription or payment may be required)

Increasing Number of Workers in Self-Insured Health Plans

MONDAY, Dec. 3 (HealthDay News) -- There has been a recent increase in the percentage of workers in the private sector who are enrolled in self-insured health plans, in which the employer assumes the financial risk related to health insurance (unlike a fully-insured plan, where the insurance company assumes the risk), according to research published in the November issue of the Employee Benefit Research Institute's Notes.

More Information

Topical Simvastatin Accelerates Wound Healing in Diabetes

MONDAY, Dec. 3 (HealthDay News) -- Topically applied simvastatin accelerates wound healing by directly influencing lymphatics and indirectly via recruitment of macrophages, according to a study published in the December issue of The American Journal of Pathology.

Abstract
Full Text (subscription or payment may be required)

Physician's Briefing