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July 2007 Briefing - Diabetes & Endocrinology

Here are what the editors at HealthDay consider to be the most important developments in Diabetes & Endocrinology for July 2007. This roundup includes the latest research news from journal articles, as well as the FDA approvals and regulatory changes that are the most likely to affect clinical practice.

FDA Panel Says Avandia Should Stay Despite Heart Risks

TUESDAY, July 31 (HealthDay News) -- The widely prescribed type 2 diabetes drug Avandia (rosiglitazone) should remain on the market, despite studies that suggest it could increase the risk of myocardial infarction, U.S. Food and Drug Administration advisers said Monday.

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Elevated Cystatin C Levels Predict Pre-Diabetes

MONDAY, July 30 (HealthDay News) -- Elevated levels of cystatin C are associated with a threefold higher risk of developing pre-diabetes, according to a nested case-control study published in the July issue of Diabetes Care.

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Premature Infants Have Lower Circulating Adiponectin

MONDAY, July 30 (HealthDay News) -- Pre-term infants have lower levels of circulating adiponectin at discharge when compared with their full-term counterparts, and these levels correlate with body weight, according to a study in the July issue of the Archives of Disease in Childhood: Fetal and Neonatal Edition.

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Thiazolinediones Double Risk of Heart Failure in Diabetes

FRIDAY, July 27 (HealthDay News) -- Thiazolinediones may double the risk of heart failure in patients with type 2 diabetes, according to a report in the August issue of Diabetes Care, which was first published online in May.

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One Failed Glucose Test May Suggest Risk in Pregnancy

THURSDAY, July 26 (HealthDay News) -- Pregnant women who have one abnormal value on a glucose tolerance test are "clinically indistinguishable" from women with gestational diabetes mellitus, and both groups have insulin abnormalities compared to other women, researchers report in the July issue of Diabetes Care.

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Link Seen Between Low Cholesterol and Cancer

WEDNESDAY, July 25 (HealthDay News) -- Cardiac patients who achieve low LDL levels with statin therapy may have a slightly increased risk of cancer, but the cardiovascular benefits of statin therapy still outweigh the risks, according to study findings published in the July 31 issue of the Journal of the American College of Cardiology.

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Editorial - LaRosa
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Frequent Awakenings During Hypoglycemia in Late Sleep

WEDNESDAY, July 25 (HealthDay News) -- Hormonal changes may explain the frequent awakenings during hypoglycemic episodes in late sleep in people with diabetes, according to a report in the July issue of Diabetes.

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Immune System Affects Circadian Clock During Illness

WEDNESDAY, July 25 (HealthDay News) -- Sleepiness that commonly occurs during illness or infection may be caused by inhibition of circadian rhythm genes by the inflammatory cytokine TNF-α, according to the results of a study in cultured cells and in mice published online July 23 in the Proceedings of the National Academy of Sciences Early Edition.

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Thyroid Function Linked to Death Risk in Cardiac Patients

TUESDAY, July 24 (HealthDay News) -- In patients with heart disease, even mild thyroid dysfunction may be associated with an increased risk of death, according to the results of a study published in the July 23 issue of the Archives of Internal Medicine.

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Benefits of Drug-Eluting Stents May Outweigh Risks

MONDAY, July 23 (HealthDay News) -- The benefit of drug-eluting stents, a reduction in the risk of clinically necessary target lesion revascularization, appears to outweigh the slightly increased risk of later stent thrombosis and myocardial infarction, according to a report published in the July 31 issue of the Journal of the American College of Cardiology.

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Health Literacy Affects Survival in Elderly

MONDAY, July 23 (HealthDay News) -- In older patients, an inability to read and understand basic health information independently predicts an increased five-year risk of all-cause mortality and cardiovascular death, according to research published in the July 23 issue of the Archives of Internal Medicine.

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Drinking Soda Associated with Metabolic Syndrome

MONDAY, July 23 (HealthDay News) -- Consumption of at least one soda per day is associated with a higher risk of metabolic syndrome in middle-aged adults, according to a report published in the July 31 issue of Circulation: Journal of the American Heart Association.

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FDA Issues Class I Recall of Baxter Infusion Pumps

MONDAY, July 23 (HealthDay News) -- The U.S. Food and Drug Administration and Baxter Healthcare Corp. of Round Lake, Ill., notified health care professionals and consumers July 20 of a class I recall of the Baxter Upgraded COLLEAGUE Triple Channel Volumetric Infusion Pumps, model numbers 2M8153, 2M8163, and 2M9163.

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Dairy Intake Linked to Lower Metabolic Syndrome Risk

THURSDAY, July 19 (HealthDay News) -- Daily consumption of milk and other dairy products by middle-aged men is associated with a lower risk of metabolic syndrome, according to study findings published in the July issue of the Journal of Epidemiology and Community Health.

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Donor Hematopoietic Stem Cells Don't Produce Beta-Cells

THURSDAY, July 19 (HealthDay News) -- Hematopoietic-derived stem cells from an adult donor may not differentiate into the pancreatic beta-cells thought to help reverse diabetes when transplanted into patients, researchers report in the July issue of Diabetes.

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Oral Diabetes Drugs May Not Cut All-Cause Mortality

WEDNESDAY, July 18 (HealthDay News) -- No single agent or combination of oral antihyperglycemic agents may reduce all-cause mortality in diabetic patients more than sulfonylurea alone or no drug, according to a study in the July issue of Diabetes Care.

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High Score on Eating Index Means Lower Diabetes Risk

WEDNESDAY, July 18 (HealthDay News) -- Women who score high on the Alternate Healthy Eating Index may be less likely to develop type 2 diabetes than their counterparts who score lower on this index, researchers report in the July issue of Diabetes Care.

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No Interaction Seen Between Clopidogrel and Statins

WEDNESDAY, July 18 (HealthDay News) -- Contrary to concerns that certain statins may reduce the effectiveness of clopidogrel because both are metabolized by CYP3A4, there is no evidence that the drugs interact, according to a report in the July 24 issue of the Journal of the American College of Cardiology.

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Smokers with Diabetes May Receive Suboptimal Care

TUESDAY, July 17 (HealthDay News) -- Diabetic smokers are less likely to receive recommended diabetes care, including foot exams, hemoglobin A1C tests and eye exams, when compared with their non-smoking counterparts, according to a study in the July issue of Diabetes Care.

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Diabetic Trauma Patients at Greater Risk of Complications

TUESDAY, July 17 (HealthDay News) -- Among patients hospitalized for trauma, those with diabetes mellitus are significantly more likely than non-diabetics to develop complications and require a higher level of care, which increases the cost of their hospitalization, according to study findings published in the July issue of the Archives of Surgery.

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Older Diabetes Drugs As Good and Cheaper Than New Ones

TUESDAY, July 17 (HealthDay News) -- The first comprehensive review of literature on the relative benefits of oral diabetes drugs, published online July 17 in the Annals of Internal Medicine, concludes that older drugs are just as effective and sometimes better than new drugs for a lower price. The research was conducted by the Johns Hopkins Evidence-based Practice Center in Rockville, Md., under contract from the Agency for Healthcare Research and Quality.

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AHA Endorses Resistance Training for Heart Patients

MONDAY, July 16 (HealthDay News) -- Under proper supervision, most heart patients can safely add resistance training to an exercise program and it may have significant long-term beneficial effects on their cardiovascular and overall health, according to an American Heart Association scientific statement published in the July 31 issue of Circulation: Journal of the American Heart Association.

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Hypothalamic-Pituitary-Adrenal Axis Altered By Light in Mice

MONDAY, July 16 (HealthDay News) -- Mice exposed to shorter days during seasonal changes have changes in their feedback regulation of the hypothalamic-pituitary-adrenal axis and altered learning and memory, according to the results of a study in the July issue of Endocrinology.

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Platelets Play Role in Corpus Luteum Formation

FRIDAY, July 13 (HealthDay News) -- Platelets regulate neovascularization and luteinization during human corpus luteum formation, and platelet-derived soluble factors induce the migration of endothelial cells, according to a study in the July issue of Endocrinology.

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Higher Costs for Uninsured After Enrolling in Medicare

FRIDAY, July 13 (HealthDay News) -- Individuals who lack health insurance before becoming eligible for Medicare and who have cardiovascular disease or diabetes have more visits to the doctor, hospitalizations and health care costs after enrolling in Medicare than previously insured individuals, according to a report in the July 12 issue of the New England Journal of Medicine.

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Selenium Supplementation May Increase Diabetes Risk

THURSDAY, July 12 (HealthDay News) -- Selenium supplementation in cases of already adequate dietary selenium intake increases the risk of developing type 2 diabetes, according to a study published online July 10 in the Annals of Internal Medicine.

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Onsite Dietician Counseling Benefits Overweight Patients

THURSDAY, July 12 (HealthDay News) -- Patients who consult with a dietician during regular doctor visits may experience sustained improvements in body weight, lipid levels and blood pressure, according to the results of a study published in the July issue of the American Journal of Cardiology.

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Urban Teens' Weight, Activity Levels Affect Insulin

WEDNESDAY, July 11 (HealthDay News) -- Overweight status or low levels of physical activity correlate well with decreased insulin sensitivity and elevated insulin secretion in a population of urban black teens, according to a report in the July issue of the Archives of Pediatrics & Adolescent Medicine.

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Arthritis Medication Linked to Lower Diabetes Rates

TUESDAY, July 10 (HealthDay News) -- The commonly used antirheumatic medication hydroxychloroquine is associated with a reduced risk of diabetes in patients with rheumatoid arthritis compared with other antimalarials used to treat autoimmune diseases, according to a report in the July 11 issue of the Journal of the American Medical Association.

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Incretin Safe, Effective Treatment for Type 2 Diabetes

TUESDAY, July 10 (HealthDay News) -- Incretin therapy is an effective alternative to current hypoglycemic agents for treatment of patients with type 2 diabetes, according to a meta-analysis published in the July 11 issue of the Journal of the American Medical Association.

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High Intensity Walking Improves Blood Pressure

TUESDAY, July 10 (HealthDay News) -- Healthy older adults who incorporate some high intensity into their walking program can significantly improve muscle strength and reduce blood pressure, according to the results of a study published in the July issue of the Mayo Clinic Proceedings.

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Magazine's Ranking Omits Some Top Heart Hospitals

MONDAY, July 9 (HealthDay News) -- The U.S. News & World Report rankings of "America's Best Hospitals for Heart and Heart Surgery" fall short in identifying all the top hospitals for heart attack patients, researchers report in the July 9 issue of the Archives of Internal Medicine.

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Merck Recalls Three Lots of Invanz Due to Glass Shards

FRIDAY, July 6 (HealthDay News) -- Three lots of Invanz (ertapenem sodium) were recalled this week due to two incidents in which pieces of broken glass were found in the reconstituted solution for injection. Merck & Co., Inc., of Whitehouse Station, N.J., issued a letter to health care professionals noting that it is working closely with the U.S. Food and Drug Administration to inform its direct customers of the recall.

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Feeding-Related Neuropeptide Promotes Visceral Fat Growth

THURSDAY, July 5 (HealthDay News) -- Neuropeptide Y, a hormone involved in the neural control of feeding, may also be linked to stress-induced obesity, according to a report in the July issue of Nature Medicine.

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Thiazolidinediones Appear OK for Heart Failure Patients

WEDNESDAY, July 4 (HealthDay News) -- The use of thiazolidinediones (TZDs) is not associated with an increased risk for mortality or even hospitalization in patients with diabetes confounded by heart failure, according to a report in the July 3 issue of the Journal of the American College of Cardiology.

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Glycemic Load Can Increase Risk of Heart Disease

MONDAY, July 2 (HealthDay News) -- High dietary glycemic load increases the risk of cardiovascular disease, according to a report in the July 3 issue of the Journal of the American College of Cardiology.

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Physician's Briefing
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