Here are what the editors at HealthDay consider to be the most important developments in Diabetes & Endocrinology for July 2011. This roundup includes the latest research news from journal articles, as well as the FDA approvals and regulatory changes that are the most likely to affect clinical practice.
Testosterone Ranges Set Up for Premenopausal Women
FRIDAY, July 29 (HealthDay News) -- Using validated immunoassays, reference ranges for free, total, and bioavailable testosterone and sex hormone-binding globulin (SHBG) have been established using the fifth and 95th percentiles in premenopausal women with normal menstrual cycles, according to a study published online July 19 in The Journal of Sexual Medicine.
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Intensive Glycemic Control Does Not Improve Renal Outcome
FRIDAY, July 29 (HealthDay News) -- In older patients with type 2 diabetes, intensive glycemic control does not improve renal disease progression, but it is associated with reduction in nephropathy progression in patients with worse microvascular eye disease, higher body mass index (BMI), and lower diastolic blood pressure (DBP), according to a study published online July 20 in Diabetes Care.
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Evidence Shows Early Weight Gain Tied to Large Body Size
FRIDAY, July 29 (HealthDay News) -- Large body size in children between the ages of 5 and 6 months, and weight gain during the first two years of life have a positive association with larger body size at the ages of 5 to 13 years, according to a review published in the August issue of Obesity Reviews.
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Metabolic Syndrome Increases Primary Liver Cancer Risk
FRIDAY, July 29 (HealthDay News) -- Metabolic syndrome is a significant risk factor for the development of hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (ICC), regardless of other major risk factors for HCC and ICC, according to a study published in the August issue of Hepatology.
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More Weight Loss in Bariatric Surgery Than Standard Care
THURSDAY, July 28 (HealthDay News) -- Bariatric surgery appears to have substantially higher efficacy than standard care for reducing weight in severely obese adults, according to a review published in the August issue of Obesity Reviews.
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Fatty Acid-Induced Gut-Brain Signaling Lessens Sad Emotion
THURSDAY, July 28 (HealthDay News) -- Fatty acid-induced gut-brain signaling attenuates experimentally induced sad emotion at both the behavioral and neural levels in healthy individuals, according to a report published online July 25 in the Journal of Clinical Investigation.
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HbA1c Identifies Diabetes, Prediabetes in Acute Care
THURSDAY, July 28 (HealthDay News) -- Hemoglobin A1c (HbA1c) measurements can be used as a reliable screen for undiagnosed diabetes, prediabetes, and dysglycemia in emergency settings, according to a study published online July 20 in Diabetes Care.
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CDH13 Linked to Lowered Levels of Adiponectin
WEDNESDAY, July 27 (HealthDay News) -- A single nucleotide polymorphism (SNP) in the T-cadherin (CDH13) gene is associated with lowered adiponectin levels and an increased risk of cardiometabolic diseases, according to a study published online July 19 in Diabetes.
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Model Using HbA1c Level Improves CVD Risk Prediction
WEDNESDAY, July 27 (HealthDay News) -- Models that incorporate hemoglobin A1c (HbA1c) levels for patients with diabetes have improved predictive ability of cardiovascular disease (CVD) risk compared to classification of diabetes as a cardiovascular risk equivalent, according to a study published online July 25 in the Archives of Internal Medicine.
Intensive Glucose Lowering Offers No Benefit on Mortality
WEDNESDAY, July 27 (HealthDay News) -- Intensive glucose-lowering treatment shows no significant reduction in all-cause mortality or deaths from cardiovascular causes in adults with type 2 diabetes, according to a meta-analysis published online July 26 in BMJ.
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Limited Positive Effect of Restaurant Calorie Labeling
WEDNESDAY, July 27 (HealthDay News) -- The U.S regulation requiring fast food restaurants to add calorie labeling has not impacted the mean calories purchased at lunchtime, but some major chains have seen significant reductions, and 15 percent of customers use the information and purchase fewer calories, according to a study published online July 26 in BMJ.
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New Biomarkers of Coronary Heart Disease Identified
TUESDAY, July 26 (HealthDay News) -- In patients with type 2 diabetes, higher circulating levels of soluble receptor for advanced glycation endproducts (sRAGE), and its secreted isoform (esRAGE) are strongly associated with coronary heart disease (CHD), but not stroke, according to a study published online July 19 in Diabetes.
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Foods Prepared Away From Home Tied to Child's Energy Intake
TUESDAY, July 26 (HealthDay News) -- An increase in children's total daily energy intake from 1977 to 2006 correlated with a major shift toward increased energy from foods consumed or prepared away from home, according to a study published online July 25 in the Journal of the American Dietetic Association.
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Higher BMI Predicts Clinical Decompensation in Cirrhosis
TUESDAY, July 26 (HealthDay News) -- Higher body mass index (BMI) is a significant predictor of clinical decompensation (CD) in patients with compensated cirrhosis, independent of other previously described predictors and treatment groups, according to a study published online June 26 in Hepatology.
Dual Metabolic Defects Tied to Hypertriglyceridemia in Obese
MONDAY, July 25 (HealthDay News) -- Hypertriglyceridemia in obese men can be attributed to dual metabolic defects of increased secretion and impaired clearance of triglyceride-rich very-low-density lipoprotein1 (VLDL1), according to a study published online July 21 in Arteriosclerosis, Thrombosis, and Vascular Biology.
Meta-Analysis Shows 8 SNPs Tied to Metabolic Syndrome
MONDAY, July 25 (HealthDay News) -- Eight single nucleotide polymorphisms (SNPs) are associated with metabolic syndrome (MetS), mostly located in genes involved in dyslipidemia, according to a meta-analysis published online July 12 in Obesity Reviews.
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Personality Traits Predict BMI Changes Across Adulthood
MONDAY, July 25 (HealthDay News) -- Certain personality traits are predictors for changes in body mass index (BMI) across adulthood, but changes in those traits are mainly unrelated to BMI changes, according to a study published online July 11 in the Journal of Personality and Social Psychology.
Dentists' Findings Identify Unaware Patients With Diabetes
FRIDAY, July 22 (HealthDay News) -- Dental professionals can identify pre-diabetes and diabetes in unaware individuals through simple screening approaches, including oral and periodontal findings, according to a study published in the July issue of the Journal of Dental Research.
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Torcetrapib Tied to Improved Glycemic Control in Diabetes
WEDNESDAY, July 20 (HealthDay News) -- Addition of torcetrapib to atorvastatin-treated patients with type 2 diabetes is associated with improved glycemic control, according to a study published online July 18 in Circulation.
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Some Restaurant Foods Have More Calories Than Indicated
WEDNESDAY, July 20 (HealthDay News) -- The overall measured and stated energy content of restaurant foods is accurate, but there is considerable discrepancy between stated and measured energy content for individual food items, according to a study published in the July 20 issue of the Journal of the American Medical Association.
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Obese, Not Overweight Teens Get More Preventive Screening
MONDAY, July 18 (HealthDay News) -- More preventive screening is provided to obese adolescents than those who are overweight or normal weight, according to a study published online July 18 in Pediatrics.
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Evidence Supports Modifying Dietary Fat to Lower CV Risk
MONDAY, July 18 (HealthDay News) -- Modification of dietary fat intake, but not the reduction of total fat, is associated with a decreased risk of cardiovascular events, according to a meta-analysis published in the July issue of the Cochrane Database of Systematic Reviews.
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Faster Insulin Action With Needle-Free Jet Injection
FRIDAY, July 15 (HealthDay News) -- Insulin administration by needle-free jet injector enhances insulin absorption and reduces the duration of glucose-lowering action more than with conventional pen administration, according to a study published online June 29 in Diabetes Care.
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Vaccination Rates Up for Those With Liver Disease, Diabetes
FRIDAY, July 15 (HealthDay News) -- Vaccination rates for hepatitis A (HepA) and hepatitis B (HepB) in patients with chronic liver disease (CLD) and diabetes increased from 1999 to 2008, but remain low, according to a study published online July 2 in Hepatology.
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Unhealthy Lifestyle Factors Linked to Sexual Problems
THURSDAY, July 14 (HealthDay News) -- Unhealthy lifestyle factors are associated with sexual inactivity with a partner in sexually active men and women, with sexual dysfunction significantly more likely in men, according to a study published online May 13 in The Journal of Sexual Medicine.
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Men With Full-Time Jobs More Active Than Nonworkers
THURSDAY, July 14 (HealthDay News) -- Men with full-time employment, even in sedentary occupations, are significantly more active than healthy non-workers, according to a study published online July 12 in the American Journal of Preventive Medicine.
Fast Food Close to Home Affects Diet in Low-Income Men
WEDNESDAY, July 13 (HealthDay News) -- Availability of supermarket and grocery stores close to home is generally unrelated to diet, but low-income respondents may be sensitive to fast food availability, particularly for men with fast food chains located within 1.00 to 2.99 km of home, according to a study published in the July 11 issue of the Archives of Internal Medicine.
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Metabolic Syndrome Linked to Cavernosal Vasculopathy
WEDNESDAY, July 13 (HealthDay News) -- Patients with erectile dysfunction (ED) who have metabolic syndrome have higher prevalence of cavernosal vasculopathy than those without metabolic syndrome, and the number of metabolic syndrome components is correlated with cavernosal vasculopathy, according to a study published online July 5 in Diabetes Care.
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Novel Adipokine Links Obesity and Metabolic Syndrome
WEDNESDAY, July 13 (HealthDay News) -- Dipeptidyl peptidase 4 (DPP4) is a novel adipokine that appears to be involved in linking adipose tissue and the metabolic syndrome, according to a study published in the July issue of Diabetes.
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High-Volume Exercise Feasible After Bariatric Surgery
TUESDAY, July 12 (HealthDay News) -- Following a high-volume exercise program (HVEP) is feasible for more than 50 percent of patients who have undergone Roux-en-Y gastric bypass and gastric banding, according to a study published in the June 16 issue of Obesity.
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Similar Thyroid Risk for Brand-Name, Generic Amiodarone
TUESDAY, July 12 (HealthDay News) -- The incidence of thyroid dysfunction is similar in patients with atrial fibrillation treated with brand-name or generic formulations of amiodarone, according to a study published online July 11 in CMAJ, the journal of the Canadian Medical Association.
Insulin Sensitivity, Secretion Do Not Predict Weight Change
TUESDAY, July 12 (HealthDay News) -- In nondiabetic and prediabetic individuals, insulin sensitivity and secretion do not predict spontaneous weight changes; whereas, baseline waist circumference is a positive, independent predictor of weight gain and loss, according to a study published in the July issue of Diabetes.
Traditional Diabetes Classifications Apply to Youths
MONDAY, July 11 (HealthDay News) -- Most youths with diabetes have characteristics similar to traditional descriptions of type 1 and type 2 diabetes, according to a study published in the July issue of Diabetes Care.
Weight Loss and Weight Loss Maintenance Have Low Overlap
MONDAY, July 11 (HealthDay News) -- There is little overlap between the practices used to lose weight and those used to maintain weight loss, according to a study published online July 5 in the American Journal of Preventive Medicine.
Early Metformin Therapy Prevents, Delays PCOS in Girls
MONDAY, July 11 (HealthDay News) -- Early metformin therapy in girls with low birth weight and precocious puberty (LBW-PP) prevents or delays the development of hirsutism, androgen excess, oligomenorrhea, and polycystic ovary syndrome (PCOS), according to a study published online June 1 in the Journal of Clinical Endocrinology & Metabolism.
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Decrease in BP Precedes Death in Patients With Diabetes
FRIDAY, July 8 (HealthDay News) -- A significant decline in systolic and diastolic blood pressure (BP) is seen in the years preceding death in adults with diabetes, according to a study published in the July issue of Diabetes Care.
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Metformin/Rosiglitazone Tied to Early Decrease in Diabetes
FRIDAY, July 8 (HealthDay News) -- Low-dose metformin/rosiglitazone therapy is associated with an initial delay in development of type 2 diabetes in individuals with impaired glucose tolerance, but it did not affect the worsening insulin resistance and β-cell dysfunction that occurs over time, according to a study published in the July issue of Diabetes Care.
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Control of United States Obesity Epidemic Possible
THURSDAY, July 7 (HealthDay News) -- Obesity rates in the United States are continuing to rise, but control and reversal of the epidemic is possible by strategic implementation of national-level policies, according to a June report published by the Robert Wood Johnson Foundation (RWJF) and the Trust for America's Health.
Prepregnancy Heme Iron Intake Linked to Diabetes Risk
THURSDAY, July 7 (HealthDay News) -- The intake of dietary heme iron before pregnancy is associated with an increased risk of developing gestational diabetes mellitus (GDM), according to a study published in the July issue of Diabetes Care.
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Obesity Tied to Higher Risk of Breast Surgery Complications
THURSDAY, July 7 (HealthDay News) -- Obesity is associated with a significantly higher risk of complications following breast surgery, according to a study published online June 9 in Plastic and Reconstructive Surgery.
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Lopinavir-Ritonavir Treatment Tied to Adrenal Dysfunction
TUESDAY, July 5 (HealthDay News) -- Postnatal treatment with lopinavir-ritonavir (LR) for newborn children of HIV-1 infected mothers who were exposed to LR in utero have an increased risk of transient adrenal dysfunction, according to a study published in the July 6 issue of the Journal of the American Medical Association.
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Vitamin D Supplementation Safe and Effective in Pregnancy
FRIDAY, July 1 (HealthDay News) -- Daily 4000 IU vitamin D supplementation from 12 to 16 weeks of gestation is safe and effective in achieving vitamin D sufficiency in pregnant women and their neonates, according to a study published in the July issue of the Journal of Bone and Mineral Research.
Pregravid Cardiometabolic Risk Factors Linked to GDM
FRIDAY, July 1 (HealthDay News) -- Women with pregravid cardiometabolic risk factors are at significantly higher risk of developing gestational diabetes mellitus (GDM), according to a study published in the July issue of the American Journal of Obstetrics & Gynecology.
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Gastric Bypass Tied to Lower Pro-Inflammatory Proteins
FRIDAY, July 1 (HealthDay News) -- Laparoscopic Roux-en-Y gastric bypass surgery (RYGB) reduces pro-inflammatory biomarkers and increases the levels of anti-inflammatory proteins, according to a study published online March 24 in Surgery for Obesity and Related Diseases.
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Soluble Fiber, Vigorous Activity Lower VAT Accumulation
FRIDAY, July 1 (HealthDay News) -- Increased soluble fiber intake and vigorous physical activity significantly reduce the rate of visceral adipose tissue (VAT) accumulation in African- and Hispanic-Americans, according to a study published in the June 16 issue of Obesity.
