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June 2011 Briefing - Diabetes & Endocrinology

Here are what the editors at HealthDay consider to be the most important developments in Diabetes & Endocrinology for June 2011. This roundup includes the latest research news from journal articles, as well as the FDA approvals and regulatory changes that are the most likely to affect clinical practice.

Poorer Thyroid Cancer Survival in African-Americans

THURSDAY, June 30 (HealthDay News) -- African-Americans (AAs) with thyroid cancer have a poorer survival rate than whites, which may be attributed to differences in disease characteristics, according to a study published online June 21 in Ethnicity & Disease.

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Incentives Negatively Impact Non-Incentivized Activities

WEDNESDAY, June 29 (HealthDay News) -- Incentives may have a detrimental impact on non-incentivized activities of quality of care in the long-term, according to a study published online June 28 in BMJ.

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Higher Mortality in Obese, Low Occupational-Class Women

WEDNESDAY, June 29 (HealthDay News) -- For women who have never smoked, low socioeconomic status is linked to a higher prevalence of obesity and higher mortality rates from cardiovascular disease, according to a study published online June 28 in BMJ.

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Obesity in Children and Adolescents Linked to Media

MONDAY, June 27 (HealthDay News) -- Media, and specifically television viewing, may be correlated with childhood and adolescent obesity, which is related in part to advertising of unhealthy foods, according to a policy statement issued by the American Academy of Pediatrics (AAP) and published online June 27 in Pediatrics.

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Simvastatin Tops Ezetimibe for Endothelial Protection

FRIDAY, June 24 (HealthDay News) -- Simvastatin is more effective than ezetimibe in treating patients with high cholesterol levels, but treatment with a combination is most beneficial, according to a study published online May 30 in the Journal of Internal Medicine.

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IOM Addresses Prevention of Obesity in Young Children

FRIDAY, June 24 (HealthDay News) -- Encouraging more physical activity and limiting television and other media use as well as requiring child care providers to promote healthy sleeping practices are a few of the recommendations in a new report from the Institute of Medicine that is part of an effort to reduce obesity in very young children.

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Obese Teen Girls Have Higher Nicotine Addiction Risk

FRIDAY, June 24 (HealthDay News) -- Obese adolescent females have a significantly increased risk of nicotine addiction in young adulthood, which is strongly predicted by family smoking, according to a study published online June 21 in the Journal of Adolescent Health.

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Specific Diet, Lifestyle Factors Tied to Long-Term Weight Gain

WEDNESDAY, June 22 (HealthDay News) -- Specific dietary and lifestyle behaviors are independently associated with long-term weight gain, according to a study published in the June 23 issue of the New England Journal of Medicine.

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Increased Prevalence of Diabetic Kidney Disease

WEDNESDAY, June 22 (HealthDay News) -- The prevalence of diabetic kidney disease (DKD) in the United States increased between 1988 and 2008 in proportion to the prevalence of diabetes, according to a study published online June 22/29 in the Journal of the American Medical Association.

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Obesity Linked to Lower IVF Pregnancy, Live Birth Rates

WEDNESDAY, June 22 (HealthDay News) -- Women with a body mass index (BMI) of 40 kg/m² or more who undergo in vitro fertilization (IVF) have a significantly reduced likelihood of clinical pregnancy and live birth than women with normal BMI, according to a study published in the July issue of Obstetrics & Gynecology.

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Antirheumatic Drugs Linked to Lower Diabetes Risk

TUESDAY, June 21 (HealthDay News) -- Treatment of rheumatoid arthritis (RA) or psoriasis with biologic disease-modifying antirheumatic drugs (DMARDs), such as tumor necrosis factor (TNF) inhibitors, methotrexate, and hydroxychloroquine, may reduce the risk of newly recorded diabetes mellitus (DM), according to a study published in the June 22/29 issue of the Journal of the American Medical Association.

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Intensive-Dose Statins Linked to Increased Diabetes Risk

TUESDAY, June 21 (HealthDay News) -- Intensive-dose statin therapy may be associated with an increased risk of new-onset diabetes and a lower risk of cardiovascular events, according to a meta-analysis published in the June 22/29 issue of the Journal of the American Medical Association.

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Safe Weight Loss Guidelines Issued for Athletes

TUESDAY, June 21 (HealthDay News) -- Weight loss and weight maintenance for athletes and active individuals should be encouraged in a safe way, based on scientific evidence and with advice from appropriately trained health care personnel and athletic trainers, according to recommendations published in the May-June issue of the Journal of Athletic Training.

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Three-Year Retinal Screening Intervals Recommended

MONDAY, June 20 (HealthDay News) -- Retinal screening every three years can be recommended in patients with mild type 2 diabetes and no retinopathy, according to a study published in the June issue of Diabetes Care.

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Medication at Bedtime Gives Better BP Control in Diabetes

MONDAY, June 20 (HealthDay News) -- In patients with diabetes, taking one or more hypertension medications at bedtime gives better blood pressure control and major cardiovascular event risk reduction compared to morning medication, according to a study published in the June issue of Diabetes Care.

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Food Stores Near Schools Not Tied to Obesity in Students

MONDAY, June 20 (HealthDay News) -- The presence of food stores with unhealthful food near high schools in Maine has no significant impact on the obesity risk of students, according to a study published in the July issue of the Journal of Nutrition Education and Behavior.

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Many Primary Care Physicians Not Addressing Weight Issues

FRIDAY, June 17 (HealthDay News) -- A large number of primary care physicians (PCPs) do not offer adequate counseling for weight status for adults or children, according to two studies published in the July issue of the American Journal of Preventive Medicine.

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CDC: Small Percent of Youth Meet Physical Activity Goals

THURSDAY, June 16 (HealthDay News) -- Only a small percentage of youth have met the objective for aerobic and muscle-strengthening activities outlined in the Healthy People 2020 (HP 2020) physical activity guidelines, and daily consumption of sugar-sweetened beverages (SSBs) is high, especially among male and black youth, according to two reports in the June 17 issue of the U.S. Centers for Disease Control and Prevention's Morbidity and Mortality Weekly Report.

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FDA: Diabetes Drug May Up Risk of Bladder Cancer

THURSDAY, June 16 (HealthDay News) -- The U.S. Food and Drug Administration has warned consumers and health care professionals that pioglitazone (Actos) may increase the risk of bladder cancer when used for more than one year.

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Gene Mutation Tied to Increased Vitamin D Sensitivity

THURSDAY, June 16 (HealthDay News) -- Mutations in CYP24A1 are associated with increased sensitivity to vitamin D in patients with idiopathic infantile hypercalcemia, and may be a potential genetic risk factor for the development of symptomatic hypercalcemia in otherwise healthy infants, according to a study published online June 15 in the New England Journal of Medicine.

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Vitamin D Supplementation Widely Recommended

THURSDAY, June 16 (HealthDay News) -- Depending on age and clinic circumstances, vitamin D supplementation at suggested daily-intake and tolerable upper-limit levels is widely recommended, particularly for those individuals at risk of deficiency, according to the Endocrine Society's guidelines published online June 6 in The Journal of Clinical Endocrinology & Metabolism.

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Unequal Care Access for Children With Public Insurance

THURSDAY, June 16 (HealthDay News) -- Access to outpatient care is restricted for children with public insurance compared to those with private insurance, according to a study published in the June 16 issue of the New England Journal of Medicine.

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Increased Recurrent Stroke Risk in Type 2 Diabetes

WEDNESDAY, June 15 (HealthDay News) -- Patients enrolled in the Stroke Prevention by Aggressive Reduction in Cholesterol Levels (SPARCL) trial who have type 2 diabetes may have increased incidence of recurrent stroke and cardiovascular events, but the effect of atorvastatin treatment is independent of whether the patients have type 2 diabetes, or metabolic syndrome (MetS), according to a study published online June 13 in the Archives of Neurology.

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Life Expectancy in U.S. Counties Below Many Nations

WEDNESDAY, June 15 (HealthDay News) -- Most counties within the United States fall behind the international frontier with the best life expectancies in the world, according to a study published online June 15 in Population Health Metrics.

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Similar Number for Outpatient, Inpatient Malpractice Claims

TUESDAY, June 14 (HealthDay News) -- The number of paid malpractice claims is similar in both inpatient and outpatient settings, according to a study published in the June 15 issue of the Journal of the American Medical Association.

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Lengthy TV Viewing Tied to Increased Morbidity, Mortality

TUESDAY, June 14 (HealthDay News) -- Prolonged television viewing is associated with an increased risk of developing type 2 diabetes, fatal or nonfatal cardiovascular disease, and all-cause mortality, according to a meta-analysis published in the June 15 issue of the Journal of the American Medical Association.

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Ethnicity Not Linked to Screening for Diabetes

TUESDAY, June 14 (HealthDay News) -- In an insured population presenting for routine care, minority status has not been found to be an independent factor for diabetes screening, despite being recommended by the American Diabetes Association (ADA), according to a study published in the June issue of Diabetes Care.

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HbA1c Testing Can Be Used for Diabetes Diagnosis

MONDAY, June 13 (HealthDay News) -- Diabetes can be diagnosed and managed by measuring blood concentrations of hemoglobin A1c (HbA1c), according to evidence-based guidelines approved by the American Diabetes Association (ADA) and published in the June issue of Diabetes Care.

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Reduction in Body Mass May Improve Hypothalamic Activity

THURSDAY, June 9 (HealthDay News) -- Massive reduction in the body mass of obese individuals may improve hypothalamic dysfunctional activity, as detected by functional magnetic resonance imaging (fMRI), and may increase anti-inflammatory activity in the cerebrospinal fluid (CSF), according to a study published in the June issue of Diabetes.

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Novel Loci Tied to Fasting Glucose Levels in Children

THURSDAY, June 9 (HealthDay News) -- Novel fasting glucose loci previously identified in adults may be associated with altered fasting glucose levels in healthy children and adolescents, according to a review published in the June issue of Diabetes.

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Gene Mutation Links Hormone Resistance, Acrodysostosis

WEDNESDAY, June 8 (HealthDay News) -- A germ-line mutation found within the cyclic adenosine monophosphate (cAMP) signaling pathway may explain the association between congenital bone dysplasia and resistance to several hormones in patients with acrodysostosis, according to a study published online June 9 in the New England Journal of Medicine.

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Subcutaneous Insulin Promotes Liver Glucose Metabolism

WEDNESDAY, June 8 (HealthDay News) -- Increased fasting gluconeogenesis (GNG) and glycogen cycling is seen in patients with poorly controlled type 1 diabetes (T1D), but continuous subcutaneous insulin infusion (CSII) improves these abnormalities, according to a study published in the June issue of Diabetes.

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DASH-Style Diet Linked to Lower BMI in Adolescent Girls

TUESDAY, June 7 (HealthDay News) -- A higher adherence to a Dietary Approach to Stop Hypertension (DASH)-style diet by girls between the ages of 9 and 19 years is associated with a consistently lower body mass index (BMI), according to a study published in the June issue of the Archives of Pediatrics & Adolescent Medicine.

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Youth Bear Large Burden of Global Death, Disease

TUESDAY, June 7 (HealthDay News) -- Youths between the ages of 10 and 24 years carry 15.5 percent of the global burden of disability-adjusted life-years (DALYs), according to a study published online June 7 in The Lancet.

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Adding Zoledronic Acid Improves Breast CA Survival

MONDAY, June 6 (HealthDay News) -- Adding zoledronic acid to either anastrozole or tamoxifen improves disease-free survival in women with endocrine-receptor-positive breast cancer who are receiving adjuvant endocrine therapy, according to a study published online June 4 in The Lancet Oncology.

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Paroxetine With Pravastatin Raises Blood Glucose Levels

MONDAY, June 6 (HealthDay News) -- Co-administration of paroxetine and pravastatin is associated with an increase in blood glucose levels, especially in patients with diabetes, according to a study published online May 25 in Clinical Pharmacology & Therapeutics.

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Interpregnancy BMI Increase Tied to Gestational Diabetes

FRIDAY, June 3 (HealthDay News) -- Women who gain body mass index (BMI) units between their first and second pregnancies are at an increased risk of developing gestational diabetes mellitus (GDM) in the second pregnancy, according to a study published in the June issue of Obstetrics & Gynecology.

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Coronary Artery Calcium Score May Predict Mortality Risk

THURSDAY, June 2 (HealthDay News) -- A higher coronary artery calcium (CAC) score may be an independent predictor of mortality in patients with diabetes, according to a study published in the May issue of Diabetes Care.

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Sleep Apnea Improvement Maintained After Weight Loss

THURSDAY, June 2 (HealthDay News) -- Obese men with moderate to severe obstructive sleep apnea who followed a very low energy diet may maintain their initial improvements one year later, according to a study published online June 1 in BMJ.

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Iodine Deficiency Prevalent in U.K. Female Teens

THURSDAY, June 2 (HealthDay News) -- Iodine deficiency is prevalent in adolescent girls in the United Kingdom, according to a study published online June 2 in The Lancet.

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Clinical Correlates Found for Steatohepatosis Progression

WEDNESDAY, June 1 (HealthDay News) -- Most patients with nonalcoholic steatohepatosis (NASH) who develop hepatocellular carcinoma (HCC) are male and have high rates of obesity, diabetes, and hypertension, according to a study published in the May issue of Clinical Gastroenterology and Hepatology.

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Omental Adipocyte Hypertrophy Tied to Lipid Profile

WEDNESDAY, June 1 (HealthDay News) -- In women, omental, but not subcutaneous, adipocyte hypertrophy is correlated with an altered lipid profile, including hypertriglyceridemia, according to a study published in the May issue of Diabetes.

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Late Sleeping Tied to Dietary Habits and Time of Eating

WEDNESDAY, June 1 (HealthDay News) -- Sleep timing is associated with poor health behaviors and increased calorie intake after 8:00 pm, according to a study published online April 28 in Obesity.

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Physician's Briefing
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