Here are what the editors at HealthDay consider to be the most important developments in Diabetes & Endocrinology for May 2009. This roundup includes the latest research news from journal articles, as well as the FDA approvals and regulatory changes that are the most likely to affect clinical practice.
Signaling Pathway Mediates Steroid-Induced Diabetes
THURSDAY, May 28 (HealthDay News) -- Steroid-induced pancreatic β-cell dysfunction and diabetes mellitus are mediated through a cellular signaling pathway that, when blocked, can restore β-cell function, according to a study published online May 14 in Endocrinology.
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Childhood Type 1 Diabetes Set to Double in Europe by 2020
THURSDAY, May 28 (HealthDay News) -- Childhood type 1 diabetes cases are on the rise in Europe, and are set to double among the under-fives by 2020 compared to 2005, according to a study published online on May 28 in The Lancet.
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Computerized Prescription Order Errors a Risk for Patients
THURSDAY, May 28 (HealthDay News) -- Computerized provider order entry systems are prone to input errors that may put patients at risk, according to a study published in the May 25 issue of the Archives of Internal Medicine.
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Focus on Meaningful Work Protects Doctors From Burnout
THURSDAY, May 27 (HealthDay News) -- Academic faculty physicians who focus on what they find most meaningful are less likely to experience burnout, according to a study published in the May 25 issue of the Archives of Internal Medicine.
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Better Rat Model of Epilepsy in Women Developed
WEDNESDAY, May 27 (HealthDay News) -- A better animal model of epilepsy in women has been developed where the animals retain reproductive function, which may allow better study of epilepsy where seizures occur during specific stages of the menstrual cycle, according to a study published online May 14 in Endocrinology.
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Gene Finding May Influence Kidney Transplant Outcomes
WEDNESDAY, May 27 (HealthDay News) -- Kidney transplant recipients who have T allelic variants in exons 21 or 26 of the ABCB1 gene may have a greater likelihood of several adverse events related to cyclosporine A, according to research published online May 21 in the Journal of the American Society of Nephrology.
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U.K. Initiative Has Unclear Effects on Diabetes Care
WEDNESDAY, May 27 (HealthDay News) -- Since the late 1990s, the management of diabetes has improved in the United Kingdom, but it may not be a direct result of the quality and outcomes framework introduced in 2004, according to a study published online May 27 in BMJ.
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Obese and Diabetic Youth Have Carotid Abnormalities
WEDNESDAY, May 27 (HealthDay News) -- Young people who are obese or who have type 2 diabetes mellitus have abnormalities in the carotid artery that should serve as an alert to increased risk of stroke and myocardial infarction in adulthood, according to a study published online on May 26 in Circulation.
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Balance Dysfunction Common in American Adults
TUESDAY, May 26 (HealthDay News) -- Disrupted balance as a result of vestibular dysfunction is common among American adults and is a significant contributor to the incidence of falls, according to a study published in the May 25 issue of the Archives of Internal Medicine.
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Triglyceride Level Associated with Diabetic Neuropathy
TUESDAY, May 26 (HealthDay News) -- The progression of diabetic neuropathy is associated with elevated triglycerides in the blood and with decreased conduction of the peroneal motor nerve, according to a study published online May 1 in Diabetes.
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Gestational Diabetes Provides a Chance to Educate Patients
TUESDAY, May 26 (HealthDay News) -- Because women with gestational diabetes are at increased risk of subsequently developing type 2 diabetes, increasing awareness among both physicians and patients about the risk can be used as an opportunity to promote behavior that may delay or prevent the disease, according to a study published in the May 23 issue of The Lancet.
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Daily Glucose Self-Monitoring May Reduce Macrosomia Risk
MONDAY, May 25 (HealthDay News) -- Daily glucose self-monitoring in women with diet-treated gestational diabetes may be associated with a lower risk of delivering an oversized infant than routine weekly monitoring, according to research published in the June issue of Obstetrics & Gynecology.
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Telemedicine Benefits Children With Type 1 Diabetes
FRIDAY, May 22 (HealthDay News) -- In children with type 1 diabetes, a school-based telemedicine program may lead to better outcomes, according to a study published online May 22 in the Journal of Pediatrics.
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Intensive Glucose Lowering Reduces Diabetics' Heart Risks
FRIDAY, May 22 (HealthDay News) -- In patients with type 2 diabetes, an intensive glucose-lowering regimen significantly reduces coronary events without increasing the risk of death, according to a study published in the May 23 issue of The Lancet.
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Fenofibrate May Help Prevent Amputations in Diabetics
FRIDAY, May 22 (HealthDay News) -- In patients with type 2 diabetes, fenofibrate may lower the risk of minor amputation, according to a study published in the May 23 issue of The Lancet.
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Turmeric Component Reduces Weight Gain in Obesity Model
FRIDAY, May 22 (HealthDay News) -- A component of the spice turmeric blocks the growth and development of fat cells and reduces weight gain in a mouse model of obesity, according to a study in the May issue of the Journal of Nutrition.
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Cellular Pathway Mediates Longevity Due to Diet
FRIDAY, May 22 (HealthDay News) -- A component of a nutrient-sensing cellular signaling pathway plays an important role in the increased lifespan resulting from dietary restriction, according to a study published online May 22 in PLoS Genetics.
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Overnight Hemodialysis Improves Urea Reduction
THURSDAY, May 21 (HealthDay News) -- Compared to conventional four- to five-hour hemodialysis, long overnight dialysis lasting six to seven hours results in a better urea reduction ratio and less anemia, according to a study published online on May 21 in the Clinical Journal of the American Society of Nephrology.
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Breast Tumors Linked to Depression and Anxiety
THURSDAY, May 21 (HealthDay News) -- The mere presence of breast tumors in rats is associated with depression and anxiety, according to a study published online May 18 in the Proceedings of the National Academy of Sciences.
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Democrats Set Ambitious Goal for Health Care Reform
THURSDAY, May 21 (HealthDay News) -- Congressional Democrats face formidable challenges in their efforts to pass health care reform legislation by July 31, but physicians can take the lead to ensure changes are enacted, according to two perspectives published online May 20 in the New England Journal of Medicine.
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Statins May Cut Liver Cancer and Cholecystectomy Risks
THURSDAY, May 21 (HealthDay News) -- Statin use is associated with reduced risk for cholecystectomy and for liver cancer, according to two studies published in the May issue of Gastroenterology.
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Pregnancy Linked to Poorer Thyroid, Parathyroid Outcomes
THURSDAY, May 21 (HealthDay News) -- Pregnant women who undergo thyroid or parathyroid surgery are more likely to have worse clinical outcomes than non-pregnant women in terms of complications and length of stay, according to research published in the May issue of the Archives of Surgery.
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ARBs Found Ineffective for Renal Function in Diabetes
THURSDAY, May 21 (HealthDay News) -- Two angiotensin receptor blockers are ineffective in reducing renal dysfunction in patients at high risk of vascular disease such as diabetics, according to two studies published online May 19 in the Annals of Internal Medicine.
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Sticking to Work Hours Limits Very Costly
WEDNESDAY, May 20 (HealthDay News) -- Adherence to the 2003 Accreditation Council for Graduate Medical Education (ACGME) limits on work hours, and other measures aimed at reducing fatigue among residents, would be costly with no proven benefits, according to an article published in the May 21 issue of the New England Journal of Medicine.
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Dipyridamole Can Cut Risk of Hemodialysis Stenosis
WEDNESDAY, May 20 (HealthDay News) -- A combination of aspirin and dipyridamole can yield a modest reduction in the risk of arterovenous graft stenosis in patients undergoing hemodialysis, and can increase the duration of patency in new grafts, according to a study published in the May 21 issue of the New England Journal of Medicine.
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Antihypertensive Drugs Also Benefit Non-Hypertensives
WEDNESDAY, May 20 (HealthDay News) -- In everyone at risk for heart attack or stroke -- including those with normal blood pressure -- antihypertensive treatment significantly reduces the risk of coronary heart disease events and stroke, according to a study published online May 19 in BMJ.
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Personalized Support Helps Improve Diet and Fitness
WEDNESDAY, May 20 (HealthDay News) -- An e-mail-based intervention with personalized content can help people eat more healthily and do more physical activity, according to a study published online May 19 in the American Journal of Preventive Medicine.
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Fast Weight Decline in Old Age May Increase Dementia Risk
TUESDAY, May 19 (HealthDay News) -- Higher body mass index (BMI) late in life is associated with a lowered risk of developing dementia with further aging, according to a study reported in the May 19 issue of Neurology.
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Adolescent Testosterone Enhances Adult Mating
MONDAY, May 18 (HealthDay News) -- Elevated testosterone before and during adolescence enhances male mating behavior in adulthood, while increased testosterone before adolescence affects the size of various brain areas associated with mating behavior in juveniles, according to a study published online May 7 in Endocrinology.
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Hypoglycemia More Common in Chronic Kidney Disease
THURSDAY, May 14 (HealthDay News) -- Patients with chronic kidney disease (CKD) may be at higher risk of hypoglycemia, even in the absence of diabetes, according to research published online May 7 in the Clinical Journal of the American Society of Nephrology.
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Hypothyroidism Linked to Liver Cancer in Women
THURSDAY, May 14 (HealthDay News) -- Hypothyroidism is associated with a three-fold higher risk of developing liver cancer in women, even among those without major risk factors, according to a study in the May issue of Hepatology.
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More Exercise May Provide Greater Gains in Heart Disease
THURSDAY, May 14 (HealthDay News) -- A program featuring greater amounts of exercise and energy expenditure may be preferable to standard cardiac rehabilitation exercise in overweight patients with coronary heart disease, according to research published online May 11 in Circulation.
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Diabetes Linked to Death After a Heart Attack
WEDNESDAY, May 13 (HealthDay News) -- Patients who have had a heart attack have a higher risk of death or hospitalization for heart failure if they have diabetes mellitus, according to a study in the May issue of JACC: Cardiovascular Imaging.
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Women Are Forgoing Health Care More Than Men
WEDNESDAY, May 13 (HealthDay News) -- Cost-related access problems disproportionately affect women, with 52 percent in 2007 reporting problems gaining access to the heath care they needed, compared with 39 percent of men, according to a report published May 11 by The Commonwealth Fund.
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Antioxidants Block Beneficial Effects of Exercise
TUESDAY, May 12 (HealthDay News) -- Oxidative stress resulting from exercise increases insulin sensitivity and promotes the body's own antioxidant defense, a response that is blocked by taking antioxidants such as vitamin C, according to a study published online May 11 in the Proceedings of the National Academy of Sciences.
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Kidney Disease Preventive Care Linked to Heart Protection
MONDAY, May 11 (HealthDay News) -- People with chronic kidney disease (CKD) who receive preventive care may have a lower risk of cardiovascular mortality and morbidity, according to research published online May 7 in the Journal of the American Society of Nephrology.
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Diabetes Drug Reduces Insulin Secretion of β-Cells
MONDAY, May 11 (HealthDay News) -- The antidiabetic drug pioglitazone may preserve pancreatic β-cell function by reducing insulin secretion at intermediate glucose concentrations and reducing the energy metabolism of the cells, according to a study published online April 30 in Endocrinology.
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Calorie-Restricted Diet Improves Insulin Sensitivity
MONDAY, May 11 (HealthDay News) -- Calorie-restricted (CR) diets initially alter the insulin sensitivity of the liver and only later change the insulin sensitivity of muscles as the body adapts to the reduced caloric intake, according to a study published in the May issue of Gastroenterology.
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Monthly Testosterone Effective as a Male Contraceptive
FRIDAY, May 8 (HealthDay News) -- Monthly injections of testosterone can provide effective reversible contraception for healthy fertile men without adverse effects, according to a study first published online on March 17 in the Journal of Clinical Endocrinology & Metabolism.
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Visceral Fat-Depression Link Explored in Women
WEDNESDAY, May 6 (HealthDay News) -- Middle-aged women with depression tend to have more visceral fat than their nondepressed counterparts, which could explain why they are at higher risk for diabetes and cardiovascular disease, according to a study published online April 27 in Psychosomatic Medicine.
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Medical Center Press Releases Often Lacking Key Details
TUESDAY, May 5 (HealthDay News) -- Press releases from academic medical centers may often overstate the importance of research findings while failing to acknowledge relevant limitations of the studies, according to research published in the May 5 Annals of Internal Medicine.
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Pancreas Graft Function Affects Survival in Diabetics
MONDAY, May 4 (HealthDay News) -- Patients with type 1 diabetes and severe renal dysfunction who receive a simultaneous pancreas-kidney transplant have better survival if the pancreas remains functional a year after the transplant, according to a study published online ahead of print April 30 in the Clinical Journal of the American Society of Nephrology.
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Progesterone Activator Involved in Endometriosis
MONDAY, MAY 4 (HealthDay News) -- Women with endometriosis have impaired expression and cycle-dependent regulation of a progesterone receptor co-activator, which may explain progesterone resistance in endometrium from these women, according to a study published online April 23 in Endocrinology.
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Income, Education Associated With Diet Cost and Quality
MONDAY, May 4 (HealthDay News) -- People with higher socioeconomic status and educational levels are more likely to consume a costly but high-quality diet of lower-energy-density foods, according to a study published in the May issue of the Journal of the American Dietetic Association.
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Wrong Approach to Obesity Can Alienate Patients
FRIDAY, May 1 (HealthDay News) -- When physicians tackle the issue of obesity with their black patients, they may unintentionally alienate them if they do not use the right timing and approach, according to a study published in the May issue of the Journal of General Internal Medicine.
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More Americans Reporting Disability
FRIDAY, May 1 (HealthDay News) -- The number of Americans reporting disabilities rose by 7.7 percent from 44.1 million in 1999 to 47.5 million in 2005, according to a report in the May 1 issue of the U.S. Centers for Disease Control and Prevention's Morbidity and Mortality Weekly Report.
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