Here are what the editors at HealthDay consider to be the most important developments in Diabetes & Endocrinology for May 2010. This roundup includes the latest research news from journal articles, as well as the FDA approvals and regulatory changes that are the most likely to affect clinical practice.
Higher Varicocele Grade Linked to Lower Sperm Density
FRIDAY, May 28 (HealthDay News) -- In men with varicocele and infertility, the grade of the varicocele is related to semen quality, and grade III varicoceles are associated with higher testosterone levels, according to research published in the May issue of Urology.
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Cardiac Event Biomarker Linked to Volume Overload
FRIDAY, May 28 (HealthDay News) -- Among stable hemodialysis patients, N-terminal probrain type natriuretic peptide (NTproBNP) may not be associated with cardiac dysfunction but appears to be dependent on factors associated with volume overload, and may also be elevated in those with malnutrition, according to a study published online May 27 in the Clinical Journal of the American Society of Nephrology.
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Baseline DPP-IV Not Found to Predict Incident Diabetes
FRIDAY, May 28 (HealthDay News) -- Fasting levels of dipeptidyl peptidase IV (DPP-IV) don't appear to predict later diabetes, according to research published in the May issue of Diabetes Care.
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In Diabetes Patients at Low CVD Risk, Aspirin Not Recommended
THURSDAY, May 27 (HealthDay News) -- Low-dose aspirin for prevention of cardiovascular disease (CVD) is reasonable for adults with diabetes who are at increased CVD risk but should not be routinely recommended for those at low CVD risk, according to a combined statement from the American Diabetes Association, the American Heart Association, and the American College of Cardiology Foundation, published online May 27 in Circulation, Diabetes Care, and the Journal of the American College of Cardiology.
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Exenatide, Rosiglitazone Combo Beneficial in Type 2 Diabetes
THURSDAY, May 27 (HealthDay News) -- The addition of exenatide and rosiglitazone to metformin in type 2 diabetes is associated with glycemic control benefits, improvements in β-cell function and insulin sensitivity, and weight loss, according to research published in the May issue of Diabetes Care.
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Early Glycemic Control Vital in Type 1 Diabetes
THURSDAY, May 27 (HealthDay News) -- Intense glycemic control early on should be attempted for individuals with type 1 diabetes to reduce the risk of complications related to diabetes arising over time, according to research published in the May issue of Diabetes.
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Inflammatory Biomarker Linked to CHD in Type 2 Diabetes
THURSDAY, May 27 (HealthDay News) -- The newly recognized inflammatory biomarker lipoprotein-associated phospholipase A2 (Lp-PLA2) appears to be a risk factor for coronary heart disease (CHD) in people with type 2 diabetes, according to research published in the May issue of Diabetes.
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FDA Changes Label on Weight-Loss Drug Orlistat
WEDNESDAY, May 26 (HealthDay News) -- The U.S. Food and Drug Administration has alerted health care providers and consumers regarding a label change to the weight-loss drug orlistat, marketed by prescription by F. Hoffmann-La Roche Ltd. as Xenical (orlistat 120 mg) and over-the-counter (OTC) without a prescription by GSK Consumer Healthcare as Alli (orlistat 60 mg), due to the potential but rare risk of severe liver injury.
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Insulin Use May Lower Cancer Risk in Type 2 Diabetes
WEDNESDAY, May 26 (HealthDay News) -- In Chinese patients with type 2 diabetes, the use of insulin appears protective against the development of cancer, though hyperglycemia may increase cancer risk, according to research published in the May issue of Diabetes.
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Benefit Seen From High-Protein Diet, Resistance Exercise
WEDNESDAY, May 26 (HealthDay News) -- In overweight individuals with type 2 diabetes, a high-protein, restricted-energy diet in combination with resistance exercise training is associated with particular improvements in body weight and composition when compared with other approaches, according to research published in the May issue of Diabetes Care.
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Increasing Exercise Linked to Decreasing Obesity in Women
TUESDAY, May 25 (HealthDay News) -- In adult women, there is a crude, graded inverse dose-response relationship between total volume of leisure-time physical activity and obesity, according to a study published in the May issue of the Journal of Epidemiology and Community Health.
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Frequent Doctor Visits Benefit Hypertensive Diabetes Patients
MONDAY, May 24 (HealthDay News) -- In hypertensive patients with diabetes, shorter intervals between encounters with physicians are associated with a faster decrease in blood pressure and earlier blood pressure normalization -- particularly intervals shorter than those currently recommended, according to a study published online May 24 in Hypertension.
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Metformin Associated With Decreased B-12
FRIDAY, May 21 (HealthDay News) -- Patients being treated with metformin to control their diabetes may have a higher risk of decreased levels of vitamin B-12 and increased homocysteine levels, according to research published in the May 20 online edition of the BMJ.
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Faster Weight Loss Appears to Yield Better Results
THURSDAY, May 20 (HealthDay News) -- People who lose greater amounts of weight initially in weight-loss attempts may experience better weight loss and maintenance results than those who lose weight gradually, according to research published in the June issue of the International Journal of Behavioral Medicine.
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Vitamin D Insufficiency Common in Young Women
THURSDAY, May 20 (HealthDay News) -- Many U.S. women of childbearing age have vitamin D insufficiency, and the current recommended dosage for prenatal vitamin D supplementation may need to be increased to reach recommended levels, according to a study in the American Journal of Obstetrics & Gynecology.
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Diabetic Retinopathy Detectors Equally Effective
THURSDAY, May 20 (HealthDay News) -- A new automated detection algorithm appears to be as effective at detecting diabetic retinopathy as an established algorithm used in a large early-detection project, according to a study published online April 16 in Ophthalmology.
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Ketogenic Diet Linked to Altered Insulin Sensitivity
WEDNESDAY, May 19 (HealthDay News) -- In rats, the use of a ketogenic diet appears to negatively affect glucose homeostasis, though the effects are quickly reversed when the diet is halted, according to research published online April 28 in Endocrinology.
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In Prostate Cancer, Selective Alendronate Use Cost-Effective
TUESDAY, May 18 (HealthDay News) -- A bone mineral density test followed by selective use of alendronate for fracture prevention in men beginning androgen deprivation therapy for localized prostate cancer is cost-effective, according to research published in the May 18 issue of the Annals of Internal Medicine.
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Obesity, Diabetes Associated With Low Free Testosterone
MONDAY, May 17 (HealthDay News) -- Among obese men older than 45 years of age, 40 percent of those without diabetes and half of those with diabetes have below-normal free testosterone (FT) concentrations, according to research published online in Diabetes Care.
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Pernicious Anemia Patients at Higher Risk for Hip Fractures
FRIDAY, May 14 (HealthDay News) -- Even after years of vitamin B-12 therapy, people with pernicious anemia are still at increased risk for hip fractures, which suggests a mechanism other than B-12 deficiency could be driving their vulnerability, according to research published in the April issue of Gastroenterology.
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Many General Internists Leave Field by Mid-Career
FRIDAY, May 14 (HealthDay News) -- Roughly one out of six general internists are leaving internal medicine by mid-career, a substantially higher proportion compared to internal medicine subspecialists, according to survey results published April 29 in the Journal of General Internal Medicine.
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Early Child Care May Affect Functioning in Teenage Years
FRIDAY, May 14 (HealthDay News) -- The quality and quantity of early child care is associated with functioning, including academic achievement, at age 15, according to a study published in the May/June issue of Child Development. Another study in the same issue found increased cortisol levels in children when they were at full-time, home-based day care versus when they were at home.
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Neuropathic Pain Increases Related Medical Costs
FRIDAY, May 14 (HealthDay News) -- Common types of neuropathic pain, such as that associated with herpes zoster or diabetes, can add substantially to health care costs related to those conditions, according to a study reported in the April issue of the Journal of Pain.
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Steps Per Day Linked to Metabolic Syndrome Prevalence
THURSDAY, May 13 (HealthDay News) -- Although public health recommendations have tended to focus on moderate-to-vigorous physical activity, an active lifestyle as measured by steps per day is associated with a reduced prevalence of both metabolic syndrome (MetS) and its cardiovascular disease (CVD) risk factors, according to research published online May 4 in the American Journal of Preventive Medicine.
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Removing Financial Incentives May Reduce Performance
WEDNESDAY, May 12 (HealthDay News) -- The focus of clinicians may change and their performance levels could drop when previously established financial incentives are removed, according to research published May 11 in BMJ.
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New FDA Program Targets Misleading Drug Advertising
WEDNESDAY, May 12 (HealthDay News) -- The U.S. Food and Drug Administration has announced the launch of a new program to educate health care providers regarding their role in making certain that advertisements and promotions for prescription drugs are truthful and not misleading.
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High BMI Partly Explains Family-Based Diabetes Risk
WEDNESDAY, May 12 (HealthDay News) -- A high body mass index (BMI) and, to some extent, specific lifestyle factors may explain a substantial part of the association between family history of diabetes and type 2 diabetes risk, according to research published in the April issue of Diabetes Care.
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High-Dose Vitamin D Linked to Falls, Fractures in Women
TUESDAY, May 11 (HealthDay News) -- Older women receiving an annual large dose of vitamin D may have an increased risk of falls and fractures, according to research published in the May 12 issue of the Journal of the American Medical Association.
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In Women With Diabetes, More Bran Tied to Lower Mortality
MONDAY, May 10 (HealthDay News) -- Increasing dietary whole grains, especially the bran component, is linked to decreased all-cause and cardiovascular disease-specific mortality in women with type 2 diabetes, according to a study published online May 10 in Circulation.
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Many Youths With Diabetes Get Too Little Exercise
MONDAY, May 10 (HealthDay News) -- Many youths with diabetes mellitus (DM), especially males with type 2 disease, do not meet recommendations for physical activity and electronic media use, according to a study published online May 10 in Pediatrics.
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Single Night of Lost Sleep Implicated in Insulin Resistance
MONDAY, May 10 (HealthDay News) -- A single night of little sleep can cause metabolic abnormalities including insulin resistance, according to research published online April 6 in the Journal of Clinical Endocrinology & Metabolism.
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Microalbuminuria Can Predict Complications in Hypertension
FRIDAY, May 7 (HealthDay News) -- Microalbuminuria independently predicts higher risk of renal and cardiovascular complications in patients with primary hypertension but without diabetes, according to research published online April 29 in the Clinical Journal of the American Society of Nephrology.
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Autonomous Motivation May Have Large Role in Weight Loss
FRIDAY, May 7 (HealthDay News) -- Autonomous motivation is a potential intervention target for increasing adherence to self-monitoring in a weight-loss program and weight loss itself, according to a study published in the May 2010 issue of the Journal of Nutrition Education and Behavior.
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Preconception Counseling Benefits Teens With Diabetes
THURSDAY, May 6 (HealthDay News) -- A preconception counseling program aimed at female teenagers with type 1 diabetes is beneficial and cost-effective, and its effects are sustained for at least nine months, according to research published in the April issue of Diabetes Care.
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Seminar Addresses State of Childhood Obesity
THURSDAY, May 6 (HealthDay News) -- Although the rapid increase in childhood obesity prevalence in developed countries may be stabilizing, rates have risen substantially since the 1970s, and efforts to prevent obesity should continue at all levels, though bariatric surgery should be used only as a last-resort treatment in extreme cases, according to a seminar published online May 6 in The Lancet.
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Everolimus-Eluting Superior to Paclitaxel-Eluting Stent
WEDNESDAY, May 5 (HealthDay News) -- Coronary everolimus-eluting stents result in superior clinical outcomes compared with paclitaxel-eluting stents, and reduced rates of target-lesion failure at one year seen with everolimus-eluting stents are consistent in all patients except those with diabetes, according to research published in the May 6 issue of the New England Journal of Medicine.
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Prognosis Varies Per Glycemic Index Pre-Revascularization
WEDNESDAY, May 5 (HealthDay News) -- Having a low -- but not too low -- glycemic index prior to surgery is optimal for best cardiovascular outcomes after coronary revascularization in patients with type 2 diabetes mellitus (DM), according to a study in the April 1 issue of the American Journal of Cardiology.
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Growth Hormone Enhances Body Composition in Athletes
TUESDAY, May 4 (HealthDay News) -- Giving growth hormone to recreational athletes -- alone in women and alone or with testosterone in men -- results in increased sprint capacity and changes in body composition, according to a study in the May 4 issue of the Annals of Internal Medicine.
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Rate of Childhood Obesity, Overweight Varies by State
MONDAY, May 3 (HealthDay News) -- In 2007, there were substantial geographic disparities in childhood overweight and obesity, with the prevalence increasing in many states from 2003 to 2007, according to data published online May 3 in the Archives of Pediatrics & Adolescent Medicine.
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