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Type of RNA Molecule Less Abundant in Diabetes

Reduced levels of microRNA may identify high-risk patients

MONDAY, Sept. 20 (HealthDay News) -- People with diabetes mellitus appear to have lower blood levels of microRNAs (miRNAs) compared with healthy individuals, and these lower levels are detectable before manifestation of the disease, according to research published in the Sept. 17 issue of Circulation Research.

Anna Zampetaki, Ph.D., of King's College London, and colleagues analyzed miRNA profiles in 80 individuals with diabetes from the Bruneck study and in 80 controls to investigate the role of miRNAs in the regulation of key metabolic, inflammatory, and antiangiogenic pathways in diabetes and their possible contribution to disease complications.

The researchers identified 13 candidate miRNAs by microarray screening; lower plasma levels of 10 of the miRNAs and a moderately higher level of one were prevalent in the diabetes group. Results were confirmed for endothelial miR-126 in the entire Bruneck cohort of 822 subjects. Lower levels of miR-15a, miR-29b, mir-126, and miR-233 and elevated levels of miR-28-3p preceded manifestations of the disease.

"We reveal a plasma miRNA signature for diabetes mellitus that includes loss of endothelial miR-126. These findings might explain the impaired peripheral angiogenic signaling in patients with diabetes mellitus," the authors write.

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