See What HealthDay Can Do For You
Contact Us

Vit D, Parathyroid Hormone Influence Glucose Metabolism

Low vitamin D linked to metabolic dysfunction only when accompanied by elevated PTH

Vit D, Parathyroid Hormone Influence Glucose Metabolism

MONDAY, June 9, 2014 (HealthDay News) -- Levels of parathyroid hormone (PTH) should be considered when evaluating the effect of vitamin D status on glucose metabolism, according to research published online May 29 in Diabetes.

Caroline K. Kramer, M.D., Ph.D., of the University of Toronto, and colleagues performed serial metabolic characterizations in 494 women during the postpartum period to evaluate the associations of vitamin D and PTH levels with glucose metabolism.

The researchers found that 32 percent of the women with prediabetes or diabetes at 12-months postpartum had both vitamin D deficiency and elevated PTH (in the highest tertile) at three-months postpartum. Using multiple-adjusted linear regression models, vitamin D insufficiency/deficiency combined with PTH in the highest tertile at three months was an independent predictor of poorer beta-cell function (P = 0.03) and insulin sensitivity (P = 0.01), and increased fasting (P = 0.03) and two-hour glucose (P = 0.002) at 12-months postpartum. Vitamin D insufficiency/deficiency with lower levels of PTH did not predict these outcomes.

"In conclusion, only vitamin D deficiency/insufficiency with increased PTH is an independent predictor of beta-cell dysfunction, insulin resistance and glycemia, highlighting the need for consideration of the PTH/25-hydroxyvitamin D axis when studying the impact of vitamin D status on glucose homeostasis," the authors write.

Full Text (subscription or payment may be required)

Physician's Briefing


HealthDay is the world’s largest syndicator of health news and content, and providers of custom health/medical content.

Consumer Health News

A health news feed, reviewing the latest and most topical health stories.

Professional News

A news feed for Health Care Professionals (HCPs), reviewing latest medical research and approvals.