Type 1 Diabetes Incidence Up in Children in Italy
Increasing temporal trend, substantial geographic variation observed
MONDAY, Sept. 20 (HealthDay News) -- The incidence of type 1 diabetes rose in Italian children from 1990 to 2003, with large geographical variation observed, according to an age-period-cohort analysis published in the September issue of Diabetes.
Graziella Bruno, M.D., of the University of Turin in Italy, and colleagues analyzed data on 5,180 incident cases between 1990 and 2003 to investigate the effects of age-period-cohort on the temporal trend of type 1 diabetes in children aged 14 and under in Italian registries.
The researchers determined the incidence rate to be 12.26 per 100,000 person-years, significantly higher for boys than for girls (13.13 versus 11.35). There was substantial geographical variation; incidence was especially high in the Trento province, at 18.67 per 100,000 person-years. An increasing temporal trend was also seen, with a yearly increment of 2.94 percent.
"Large geographical variations and an increasing temporal trend in diabetes incidence are evident among type 1 diabetic children in Italy. Age-period-cohort analysis shows that the variation over time has a linear component that cannot be ascribed to either the calendar period or the birth cohort," the authors write.