Obesity Increases Risk of Kidney Failure

Greater body mass index a risk factor for end-stage renal disease

TUESDAY, Jan. 3 (HealthDay News) -- Obesity increases the risk of kidney failure, according to study findings published in the Jan. 3 issue of the Annals of Internal Medicine.

Chi-yuan Hsu, M.D., of the University of California, San Francisco, and colleagues analyzed data on 320,252 adults who had height and weight measured during check-ups between 1964 and 1985. The patients were members of Kaiser Permanente of Northern California, a large, integrated health-care delivery system.

The researchers found a total of 1,471 cases of end-stage renal disease. After adjusting for age, sex, smoking status, heart disease, serum cholesterol and other variables, the investigators found that higher body mass index was a risk factor for end-stage renal disease.

Compared to people with normal weight (BMI of 18.5 to 24.9 kg/m2), the researchers found an adjusted relative risk for end-stage renal disease of 1.87 in the overweight group (BMI of 25 to 29.9 kg/m2), 3.57 for class I obesity (BMI 30 to 34.9 kg/m2), 6.12 for class II obesity (BMI 35 to 39.9 kg/m2), and 7.07 for the extremely obese (BMI of 40 kg/m2 or more).

"High BMI is a common, strong and potentially modifiable risk factor for end-stage renal disease," the authors write.

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