Hypoglycemia Ups Cardio Events, Mortality for Insulin-Treated
Increased risk of cardiovascular events, mortality for insulin-treated patients with type 1, 2 diabetes
WEDNESDAY, Dec. 17, 2014 (HealthDay News) -- For insulin-treated patients with type 1 and type 2 diabetes, hypoglycemia is associated with increased risk of cardiovascular events and all-cause mortality, according to a study published online Dec. 9 in Diabetes Care.
Kamlesh Khunti, M.B.Ch.B., Ph.D., M.D., from the University of Leicester in the United Kingdom, and colleagues conducted a retrospective cohort study using data from the Clinical Practice Research Datalink database for insulin-treated patients with diabetes. The authors examined the correlation between hypoglycemia and the risk of cardiovascular events and all-cause mortality.
The researchers found that the hazard ratios for cardiovascular events in those with type 1 diabetes were 1.51 (95 percent confidence interval [CI], 0.83 to 2.75) for those with a history of cardiovascular disease and 1.61 (95 percent CI, 1.17 to 2.22) for those without a history of cardiovascular disease before the index date. The hazard ratios were 1.60 (95 percent CI, 1.21 to 2.12) and 1.49 (95 percent CI, 1.23 to 1.82), respectively, for those with type 2 diabetes. The corresponding hazard ratios for all-cause mortality among those with type 1 diabetes were 1.98 (95 percent CI, 1.25 to 3.17) and 2.03 (95 percent CI, 1.66 to 2.47), respectively, and 1.74 (95 percent CI, 1.39 to 2.18) and 2.48 (95 percent CI, 2.21 to 2.79), respectively, for those with type 2 diabetes.
"Hypoglycemia is associated with an increased risk of cardiovascular events and all-cause mortality in insulin-treated patients with diabetes," the authors write.
Several authors disclosed financial ties to the pharmaceutical industry.