THURSDAY, Sept. 16 (HealthDay News) -- Restrictive impaired lung function among men without a history of cardiovascular disease or diabetes appears to be associated with fatal coronary heart disease (CHD) and incident type 2 diabetes, according to a study published in the September issue of Diabetes Care.
S. Goya Wannamethee, Ph.D., of the University College Medical School in London, and colleagues followed 4,434 men, aged 40 to 59 years, with no history of cardiovascular disease (CHD or stroke) or diabetes for up to 20 years.
During the 20 years of follow-up, the investigators found 680 major CHD events (276 fatal and 404 nonfatal) and 256 incident type 2 diabetes. After adjustment for potential confounding factors, age, and metabolic risk factors, forced vital capacity (FVC) and forced expiratory volume in 1 second (FEV1) -- but not FEV1-to-FVC ratio -- were significantly and inversely associated with fatal CHD events and incident type 2 diabetes. Lung function was found to be significantly and inversely associated with interleukin-6 and C-reactive protein. However, after further adjustment for C-reactive protein and interleukin-6, the inverse associations with type 2 diabetes for FVC and FEV1 were attenuated, but they remained significant for fatal CHD.
"Our findings confirm previous studies that have reported inverse associations between lung function and type 2 diabetes and CHD events and extend these findings further by examining the role of inflammation in explaining these associations and differentiating between fatal and nonfatal CHD events," the authors write.
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