Metabolic Syndrome Accelerates Aortic Stiffness

Speedier age-related progression seen in patients with metabolic syndrome

FRIDAY, Dec. 30 (HealthDay News) -- Aortic stiffness progresses more quickly in patients with metabolic syndrome, according to a longitudinal study in the January issue of the Journal of the American College of Cardiology.

Michel E. Safar, M.D., of the Hotel-Dieu Hospital in Paris, France, and colleagues classified 476 subjects according to cardiovascular risk factors, ranging from zero to three and more, and followed them for six years. Risk factors included hypertension, body mass index, dyslipidemia, hypertriglyceridemia and hyperglycemia.

The researchers found that at baseline, blood pressure, heart rate, plasma creatinine and aortic pulse wave velocity were significantly higher in the group with three and more cardiovascular risk factors than in those with zero to two risk factors.

During follow-up, the increase in aortic pulse wave velocity, but not in pulse pressure, was significantly higher in the group with three and more risk factors than in other groups, the researchers found. The results were unchanged after adjusting for age, gender, smoking habits and other factors.

"Metabolic syndrome is associated with an increased progression of aortic stiffness with age, supporting premature senescence in these patients," the authors write.

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