See What HealthDay Can Do For You
Contact Us

Study May Explain Cardiac Benefit of Green Tea

A component of green tea reduces the production of a vasoconstrictor

THURSDAY, Jan. 7 (HealthDay News) -- A component of green tea reduces the production of a vasoconstrictor in endothelial cells, possibly explaining the beneficial cardiovascular effects of green tea, according to a study in the January issue of Endocrinology.

Chad E.N. Reiter and colleagues from the National Institutes of Health in Bethesda, Md., investigated whether epigallocatechin gallate (EGCG), a green tea polyphenol, controlled the expression of the vasoconstrictor endothelin-1 via the transcription factor FOXO1, partially explaining the ability of EGCG to promote vasodilation.

After treatment of human aortic endothelial cells with EGCG, the researchers found that EGCG reduced endothelin-1 production and secretion. FOXO1 regulated the endothelin-1 gene via binding to the endothelin-1 promoter, and further investigation showed that EGCG activated two proteins that partially regulated FOXO1 binding to the endothelin-1 promoter.

"The reduction of endothelin-1 expression by EGCG in endothelial cells may contribute to the reduced cardiovascular morbidity and mortality associated with drinking green tea," Reiter and colleagues conclude.

Abstract
Full Text (subscription or payment may be required)

Physician's Briefing
undefined
undefinedundefined