Vibrations Reduce Fat Cell Production in Mice

Exposure to brief daily periods of vibration reduces adipogenesis by 27 percent

THURSDAY, Oct. 25 (HealthDay News) -- Mice receiving brief daily treatments of high-frequency vibrations well below what would occur during walking have reduced production of fat cells, according to a report published online Oct. 24 in the Proceedings of the National Academy of Sciences Early Edition.

Clinton T. Rubin, Ph.D., from Stony Brook University in Stony Brook, N.Y., and colleagues examined the effect of brief daily exposure to high-frequency mechanical signals on obesity and related diseases in mice.

The researchers found that 15 weeks of this treatment inhibited adipogenesis by 27 percent, lowered non-esterified free fatty acids in the liver by 43 percent, and lowered liver triglycerides by 39 percent. Further studies showed that the reduction in adipogenesis was due to a reduction in the differentiation of mesenchymal stem cells into adipocytes.

"Translated to the human, this may represent the basis for the non-pharmacologic prevention of obesity and its sequelae achieved through developmental, rather than metabolic, pathways," Rubin and colleagues conclude.

The lead author is the founder of Juvent Medical, Inc., and is involved in efforts to patent the technology described in this article.

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