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AACE: Hydrogel Increases Feelings of Satiety After Meals

Increased scores suggest potential of superabsorbent hydrogel as anti-obesity product

FRIDAY, April 23 (HealthDay News) -- Attiva -- a superabsorbent hydrogel -- may significantly increase feelings of satiety after meals and reduce hunger between meals in obese patients, according to research presented at the annual meeting of the American Association of Clinical Endocrinologists, held from April 21 to 25 in Boston.

Hassan Massoud Heshmati, M.D., chief medical officer of Boston-based Gelesis Inc. -- the manufacturer of Attiva -- and colleagues conducted a double-blind crossover study in which 95 normal, overweight and obese subjects with an average body mass index of 31 received either 2 g of Attiva or placebo before breakfast, lunch and dinner.

Compared to placebo, the researchers found that Attiva significantly increased the feeling of satiety at 30 minutes after breakfast and dinner (mean scores, 1.85 versus 1.63, and 1.98 versus 1.70, respectively), and at 60 minutes after lunch and dinner (mean scores, 2.35 versus 2.07, and 2.46 versus 2.15, respectively). They also found that Attiva was safe and well tolerated.

"This effect of Attiva on satiety, if confirmed by long-term studies, will support Attiva as a potential anti-obesity product," the authors conclude.

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