Salsalate Improves Glucose Metabolism

Also improves inflammatory parameters in obese individuals

THURSDAY, Jan. 31 (HealthDay News) -- The anti-inflammatory salsalate improves glucose metabolism and inflammatory parameters in obese non-diabetic individuals, researchers report in the February issue of Diabetes Care.

Amy Fleischman, M.D., and colleagues from Harvard Medical School in Boston, randomly assigned 20 obese non-diabetic patients to salsalate or placebo for one month.

The researchers found that salsalate significantly reduced fasting glucose, the glycemic response after oral glucose challenge and glycated albumin. Salsalate also significantly reduced fasting and glucose challenge C-peptide levels, despite no change in insulin levels, and significantly increased adiponectin levels.

"In this proof-of-principle study, salsalate reduces glycemia and may improve inflammatory cardiovascular risk indexes in overweight individuals," Fleischman and colleagues conclude.

The study received support from the pharmaceutical industry.

Full Text (subscription or payment may be required)

Physician's Briefing