Glycemic Control Linked to Neonatal Outcomes

Infants born to mothers with suboptimal control more likely to have adverse outcomes

WEDNESDAY, March 14 (HealthDay News) -- Infants born to women with gestational diabetes mellitus and suboptimal glycemic control are more likely than infants born to diabetic women with optimal glycemic control to have an adverse outcome such as high birth weight and hypoglycemia, researchers report in the March issue of Diabetes Care.

Victor H. Gonzalez-Quintero, M.D., from the University of Miami in Florida, and colleagues compared neonatal outcomes in 3,218 women with gestational diabetes mellitus, of whom 2,030 had optimal blood glucose control and 1,188 had suboptimal glucose control. All patients had singleton gestations and delivered at term.

The researchers found that 33.1 percent of infants born to mothers with suboptimal glucose control had at least one adverse outcome, including high birth weight, macrosomia, Caesarean delivery, hypoglycemia and admission to the intensive care unit or intermediate care nursery. In contrast, only 24 percent of infants born to mothers with optimal glucose control had an adverse outcome.

"Suboptimal glycemic control in women with gestational diabetes mellitus is associated with adverse neonatal outcome," Gonzalez-Quintero and colleagues conclude. "Careful monitoring of blood glucose levels and initiation of appropriate treatment are essential in the care of women with gestational diabetes mellitus."

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