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Low Pregnancy Vitamin D Levels Up Child's Diabetes Risk

Low levels increase odds of offspring developing type 1 diabetes in childhood

TUESDAY, Dec. 27 (HealthDay News) -- Lower maternal serum concentrations of 25-hydroxy-vitamin D (25-OH D) during pregnancy are associated with an increased risk of offspring developing type 1 diabetes during childhood, according to a study published in the January issue of Diabetes.

Ingvild M. Sørensen, from the Oslo University Hospital Ullevål in Norway, and colleagues investigated whether lower maternal serum concentrations of 25-OH D during pregnancy were correlated with increased childhood-onset type 1 diabetes risk. Using radioimmunoassay, 25-OH D levels were measured on late pregnancy samples from 109 women whose offspring developed type 1 diabetes before 15 years of age (cases) and from 219 control women.

The investigators found that on categorizing maternal 25-OH D levels into quartiles, there was a trend toward higher type 1 diabetes risk with lower vitamin D levels during pregnancy. Children of women with the lowest levels of 25-OH D had a more than two-fold higher odds of developing type 1 diabetes than children of women with levels above the upper quartile.

"Our results indicate an association between lower maternal serum concentrations of 25-OH D during pregnancy and increased risk of type 1 diabetes development in childhood," the authors write.

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