One Failed Glucose Test May Suggest Risk in Pregnancy

Pregnant women with one abnormal value clinically similar to those with gestational diabetes

THURSDAY, July 26 (HealthDay News) -- Pregnant women who have one abnormal value on a glucose tolerance test are "clinically indistinguishable" from women with gestational diabetes mellitus, and both groups have insulin abnormalities compared to other women, researchers report in the July issue of Diabetes Care.

Graziano Di Cianni, M.D., of the University of Pisa in Italy, and colleagues administered 100-g, three-hour oral glucose tolerance tests to 4,053 pregnant women who had been referred to two diabetes centers. Of these, 726 women (17.9 percent) were diagnosed with gestational diabetes and 759 women (18.7 percent) had one abnormal value (OAV).

Women in both groups were older than women with normal glucose tolerance and had higher body mass indexes, higher incidence of overweight and obesity, and higher serum triglyceride levels. Insulin secretion-sensitivity index scores were lower for women in the OAV and gestational diabetes groups (-34 percent and -51.7 percent, respectively) than for women with normal glucose tolerance. The index was lowest for women who had their OAV during the first hour of an oral glucose tolerance test, rather than during fasting or the second or third hours.

"These results should draw attention to the need for better understanding of the risk associated with OAV," the authors conclude. "Compared with other OAV subgroups, 1-hour OAV could be considered a more severe condition."

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