See What HealthDay Can Do For You
Contact Us

Signaling Network Identified in Prostatic Hyperplasia Model

Targets that could be exploited for therapeutics identified in rats

FRIDAY, June 5 (HealthDay News) -- Analysis of a rat model of benign prostatic hyperplasia (BPH) has identified a cellular signaling network and targets that could be exploited for therapeutics, according to a study published online May 14 in Endocrinology.

Jayoung Kim, Ph.D., from Harvard Medical School in Boston, and colleagues examined gene expression in prostate tissue from a rat model of BPH using a DNA microarray to identify possibly relevant cellular signaling pathways.

The researchers found that there was significant involvement of inflammatory pathways, including the transforming growth factor-β pathway. They also identified a series of independent interactions involving clusterin (apolipoprotein J). The expression of both transforming growth factor-β and clusterin increased in tissue from rats with BPH.

"In conclusion, we describe a novel signaling network model as a potential mechanism for histomorphologic changes in the prostate induced by persistent α(1)-adrenergic stimulation," Kim and colleagues write. "The study also implicated clusterin as a novel biochemical target for therapy."

Abstract
Full Text (subscription or payment may be required)

Physician's Briefing

HealthDay

HealthDay is the world’s largest syndicator of health news and content, and providers of custom health/medical content.

Consumer Health News

A health news feed, reviewing the latest and most topical health stories.

Professional News

A news feed for Health Care Professionals (HCPs), reviewing latest medical research and approvals.