Hormone Effects on Hepatic Lipogenesis Studied

Thyroid hormone regulates carbohydrate response element-binding protein mRNA expression

FRIDAY, June 26 (HealthDay News) -- Thyroid hormone regulates carbohydrate response element-binding protein and sterol response element-binding protein genes reciprocally, according to a study published in the July issue of Endocrinology.

Koshi Hashimoto, M.D., of Gunma University in Japan, and colleagues used methimazole to render male C57/BL6 mice hypothyroid and injected them with T3 to introduce a thyrotoxic status.

In the mouse liver, the researchers found that thyroid hormone up-regulated mouse carbohydrate response element-binding protein mRNA and protein expression. They also found that thyroid hormone up-regulated human carbohydrate response element-binding protein gene expression and promoter activities.

"These data suggest that carbohydrate response element-binding protein mRNA expression is positively regulated by thyroid hormone receptor β1 and thyroid hormone at the transcriptional level in mammals," the authors conclude. "This novel observation indicates that thyroid hormone fine-tunes hepatic lipogenesis via regulating sterol response element-binding protein-1c and carbohydrate response element-binding protein gene expression reciprocally."

Abstract
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